Bus Tickets from Orlando, FL to Knoxville, TN

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TodayMay 10
from $146
TomorrowMay 11
MonMay 12
from $99
TueMay 13
WedMay 14
ThuMay 15
FriMay 16
SatMay 17

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 13 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 12 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 12 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: May 13 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 12 at
    Departure city: Orlando
    Departure location: The Florida Mall
    Arrival time: May 13 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Orlando to Knoxville: Trip Overview

Average ticket price$112
Average bus trip duration1d
Number of daily buses3
Earliest bus departure5:15am
Distance534 miles (860 km)
Latest bus departure10:40pm

Orlando to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Orlando to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Orlando to Knoxville.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Orlando, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Orlando - Knoxville

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/08
$106
05/09
No data
Today
No data
05/11
No data
05/12
$116
05/13
No data
05/14
$98
05/15
No data
busbud logoThe cheapest trip from Orlando to Knoxville was searched and found on May 14, 2025 with a price of $98

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Knoxville, as early as possible.

You can expect to pay from $98 to $116 for a bus ticket from Orlando to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at $98 which is on 2025-05-14.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Orlando to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Orlando to Knoxville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Orlando to Knoxville.

Make a music playlist for your bus ride from Orlando to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Orlando by bus?

Bus from Orlando to Knoxville

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