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| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags | |||||
FlixBus + Greyhound | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags | |||||
| Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags | |||||
FlixBus + Greyhound | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags | |||||
| Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags |
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Compare 2 ways to go from Pittsburgh to Greenville
Busbud recommends taking the bus from Pittsburgh to GreenvilleAmong the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 18 hours 10 minutes, and with fares starting at just US$68, it presents an excellent value for a comfortable ride.
Bus Pittsburgh to Greenville, SC: Trip Overview
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Based on 87312 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$78
Pittsburgh to Greenville Bus
With Busbud, comparing and booking tickets for a bus from Pittsburgh to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Pittsburgh to Greenville.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from Pittsburgh, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Pittsburgh and Greenville?
Frequently asked questions on the trip Pittsburgh - Greenville, SC
What is the travel distance from Pittsburgh to Greenville?
Pittsburgh and Greenville are 657 km (408 miles) apart.
What are the departure and arrival locations for buses traveling from Pittsburgh to Greenville?
Buses departing from Intermodal Station in Pittsburgh will take you to Guadalajara Supermarket Bus Stop in Greenville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Greenville, SC was searched and found on Oct 13, 2025 with a price of US$80To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Greenville, SC, as early as possible.
You can expect to pay from US$80 to US$87 for a bus ticket from Pittsburgh to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$80 which is on 2025-10-13.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Pittsburgh to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Pittsburgh to Greenville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Pittsburgh to Greenville.
Tune out to the fine sounds of your best music playlist on your bus trip from Pittsburgh to Greenville while indulging in miles on end of beautiful scenic views.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from Pittsburgh to Greenville, SC?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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