Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | CheapestFastest | ||||
| Bus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Yesterday at 9:32 PM EST.
Compare 2 ways to go from Pittsburgh to Greenville
Among the sustainable travel choices, the Bus stands out as the good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just $90, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Greenville?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Pittsburgh to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pittsburgh to Greenville?
The cheapest bus tickets from Pittsburgh to Greenville start from $90. The average price for this route is around $139. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to Greenville?
The average bus trip duration from Pittsburgh to Greenville is 20h 50m, covering a distance of 408 miles (657 km). The quickest bus can get you there in 17h 35m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Greenville route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Pittsburgh to Greenville?
The earliest bus departs from Pittsburgh to Greenville at 1:30am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to Greenville?
A bus trip from Pittsburgh to Greenville generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Greenville, SC was searched and found on Jan 14, 2026 with a price of $109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Greenville, SC, as early as possible.
You can expect to pay from $109 to $192 for a bus ticket from Pittsburgh to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2026-01-14.
What's the cheapest way to go from Pittsburgh to Greenville, SC?
The Bus is the cheapest travel choice for this destinationTop traveled bus routes
People from around the world trust Busbud
Popular bus departures from Pittsburgh
- Find bus tickets from Pittsburgh to Philadelphia
- Pittsburgh to Chicago bus times and fares
- How to travel from Pittsburgh to Harrisburg
- Find bus tickets from Pittsburgh to State College
- Pittsburgh to Newark bus times and fares
- How to travel from Pittsburgh to New York City
- Find bus tickets from Pittsburgh to Washington