Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | Fastest | ||||
| Bus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Wednesday at 18:54 EST.
Compare 2 ways to travel from Pittsburgh to Greenville
Among the sustainable travel choices, the Bus stands out as a good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just £66, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Greenville?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Based on 87518 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at £66
Frequently asked questions about travelling by bus from Pittsburgh to Greenville, SC
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Pittsburgh to Greenville?
The cheapest coach tickets from Pittsburgh to Greenville start from £66. The average price for this route is around £95. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Pittsburgh to Greenville?
The average bus journey time from Pittsburgh to Greenville is 20h 50m, covering a distance of 408 miles. The fastest bus can take you there in 17h 35m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Greenville route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Pittsburgh to Greenville?
The earliest bus departs from Pittsburgh to Greenville at 01:30. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Pittsburgh to Greenville?
A bus journey from Pittsburgh to Greenville produces an estimated 16 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Greenville, SC was searched and found on 29 Jan 2026 with a price of £68To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Greenville, SC as early as possible.
You can expect to pay from £68 to £111 for a bus ticket from Pittsburgh to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £68, which is on 2026-01-29.
What's the cheapest way to go from Pittsburgh to Greenville, SC?
The Bus is the cheapest travel choice for this destination
