Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Buses San Borja - San Francisco de Borja | Terminal de Buses La Serena | Cheapest | ||||
 | Bus | San Borja | Terminal de Buses La Serena | Fastest | ||||
 | Bus | Terminal de Buses San Borja - San Francisco de Borja | Terminal de Buses La Serena | No tags | ||||
 | Bus | San Borja | Terminal de Buses La Serena | No tags | ||||
 | Bus | San Borja | Terminal de Buses La Serena | No tags |
Last refresh of the prices: Today at 5:28 PM -03.
Get from Santiago to La Serena
The journey takes about 6 hours 20 minutes, and with fares starting at just $15, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santiago and La Serena?
Stops in Santiago
- A
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - BSantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Rancagua
Estado 480, Rancagua, VI Región, Chile
Stops in La Serena
- AAmunátegui 107, La Serena, Región de Coquimbo, Chile
- B
Rotonda La Serena
Panamericana Norte 208, La Serena, Región de Coquimbo, Chile
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Frequently asked questions about travelling from Santiago, CL to La Serena, CL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santiago to La Serena?
The cheapest bus tickets from Santiago to La Serena start from $15. The average price for this route is around $33. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santiago to La Serena?
The average bus travel time from Santiago to La Serena is 6h 20m, covering a distance of 399 km. The quickest bus can get you there in 4h 35m and is operated by FlixBus.
Which bus companies service the Santiago to La Serena route?
Several major bus companies operate on this route with 81 buses available per day, including services from Pluss Chile, FlixBus, Cikbus Elité, Buses Andimar, Pullman San Andres, Buses Romani, Buses Paravias, Serena Mar, Buses Evans, Condor Bus.
What are the earliest and latest departure times for the bus from Santiago to La Serena?
The earliest bus departs from Santiago to La Serena at 6:15am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Santiago to La Serena?
A bus trip from Santiago to La Serena generates an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Santiago to La Serena?
According to Busbud customers, the highest-rated bus company on this route is Serena Mar, with an average rating of 4.0 out of 5 stars based on 12 reviews.
Which bus company has the best Wi-Fi from Santiago to La Serena?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Santiago to La Serena?
According to Busbud traveller reviews, the most punctual bus company on this route is Buses Romani, with a punctuality rating of 4.5 out of 5 stars.
Which bus company has the cleanest buses from Santiago to La Serena?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Pluss Chile, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago, CL to La Serena, CL was searched and found on Feb 14, 2026 with a price of $20To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to La Serena, CL, as early as possible.
You can expect to pay from $20 to $71 for a bus ticket from Santiago, CL to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $23 which is on 2026-02-18.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
