Skip to search formSkip to contentSkip to footer

Find the cheapest bus tickets from Santiago to La Serena

Easily compare and book your next trip with Busbud

Trusted by 65M+ travellers every year looking for bus and train tickets
Serving 2M+ bus and train routes in more than 80 countries
Dedicated customer service from booking to travel
TodayDec 3
from $14
TomorrowDec 4
from $14
TueDec 5
from $14
WedDec 6
from $14
ThuDec 7
from $14
FriDec 8
from $14
SatDec 9
from $14
SunDec 10

Cheap buses leaving today

One passenger / one way

Cheapest trips
Fastest trips
9:00PM
6h30m
3:30AM
Santiago - San Borja
Cheapest
La Serena - Terminal de Buses La Serena
Cheapest
7:15PM
6h30m
1:45AM
Santiago - San Borja
2nd Cheapest
La Serena - Terminal de Buses La Serena
2nd Cheapest
8:45PM
5h30m
2:15AM
Santiago - San Borja
Fastest
La Serena - Terminal de Buses La Serena
Fastest
8:30PM
6h
2:30AM
Santiago - Terminal de Buses San Borja - San Francisco de Borja
La Serena - Terminal de Buses La Serena
11:10PM
6h10m
5:20AM
Santiago - San Borja
La Serena - Terminal de Buses La Serena
On this page:
Bus Santiago to La Serena: Trip Overview

Bus Santiago to La Serena: Trip Overview

Average Ticket Price$25
Average Bus Trip Duration6h 30m
Number of daily buses47
Earliest bus departure7:30 AM
Distance398 km
Latest bus departure11:59 PM
Compare bus companies

Compare bus companies

If you're looking for reliable, comfortable transportation in Chile, PLUSS is a good option. The company offers a variety of routes, making it easy and affordable to get around. On any given day, 1818 buses leave from various locations, ensuring convenient departure times. With prices ranging from $14.00 to $27.00, the buses are well-maintained and comfortable. Whether you need transportation for business or pleasure, PLUSS gets you where you want to go for a fair price.

Cikbus Elité offers reliable, affordable transportation between cities in Chile. To provide convenient travel times to its customers, they have an average of 389 departures per day, with options for direct or connecting trips. With comfortable buses and prices ranging from $13.00 to $44.00, Cikbus Elité is a convenient and affordable way to travel. Their frequently updated schedules make it easy to plan your next road trip or weekend getaway. So sit back, relax, and let Cikbus Elité take care of the driving.

Cikbus Elité Santiago La Serena recent customer reviews

The best company I have ever seen. Really comfortable seats and pillows. I have problems with sleeping in buses but now I had decent rest. I recommend

Adam S.June 1, 2019

It was okay

Schirin B.February 6, 2019

If you're looking for reliable, comfortable transportation in Chile, Buses Andimar is a good option. The company offers a variety of routes, making it easy and affordable to get around. On any given day, 669 buses leave from various locations, ensuring convenient departure times. With prices ranging from $20.00 to $35.00, the buses are well-maintained and comfortable. Whether you need transportation for business or pleasure, Buses Andimar gets you where you want to go for a fair price.

Andimar Vip Santiago La Serena recent customer reviews

No one speaks english but the do try to help

Jan V.March 12, 2020

Buses Romani offers reliable, affordable transportation between cities in Chile. To provide convenient travel times to its customers, they have an average of 70 departures per day, with options for direct or connecting trips. With comfortable buses and prices ranging from $19.00 to $44.00, Buses Romani is a convenient and affordable way to travel. Their frequently updated schedules make it easy to plan your next road trip or weekend getaway. So sit back, relax, and let Buses Romani take care of the driving.

Pullman San Andres offers reliable, affordable transportation between cities in Chile. To provide convenient travel times to its customers, they have an average of 269 departures per day, with options for direct or connecting trips. With comfortable buses and prices ranging from $25.00 to $36.00, Pullman San Andres is a convenient and affordable way to travel. Their frequently updated schedules make it easy to plan your next road trip or weekend getaway. So sit back, relax, and let Pullman San Andres take care of the driving.

Chile Bus Companies: FlixBus, Tramat, Cruz del Sur

Santiago to La Serena Buses

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santiago to La Serena.

We make it our job to connect you with the most dependable bus companies that cover bus service from Santiago to La Serena.

Discover how much the bus trip from Santiago to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Information on this bus route

Daily Buses47
Earliest and Latest Bus Departures7:30AM - 11:59PM
Minimum Price$14
Average Ticket Price$25
Minimum Trip Duration5h20m
Average Bus Trip Duration6h30m
Distance398 km
Bus companies on this routePLUSS, Cikbus Elité, Buses Andimar, Buses Romani, Pullman San Andres
Frequently Asked Questions

Frequently asked questions on the trip Santiago - La Serena

The average bus ticket price from Santiago to La Serena is $25. The best way to find cheap bus tickets from Santiago to La Serena is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

The average travel time between Santiago and La Serena is around 6h 30m, although the fastest bus will take about 5h 20m.This is the time it takes to travel the 398 km that separates the two cities.

The number of buses from Santiago to La Serena can differ depending on the day of the week. On average, there are 47 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santiago to La Serena by comparing and selecting the bus that fits you travel style and budget on Busbud.

When taking the bus from Santiago to La Serena, you can travel comfortably and safely with PLUSS, Cikbus Elité, Buses Andimar.

Find cheapest prices for buses

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12-01
CA$14
12-02
CA$14
Today
CA$14
12-04
CA$14
12-05
CA$14
12-06
CA$14
12-07
CA$14
12-08
CA$14
The cheapest trip from Santiago to La Serena was searched and found on Dec 3, 2023 with a price of CA$14

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago to La Serena, as early as possible.

You can expect to pay from CA$14 to CA$41 for a bus ticket from Santiago to La Serena based on the last 2 days. You can expect to find the cheapest price for the trip at CA$14 which is on 2023-12-04.

Usually Buses Andimar, Buses Romani will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santiago to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santiago to La Serena.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to La Serena will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to La Serena.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago by bus?

Bus from La Serena to Santiago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.