Bus Tickets from Santiago, CL to La Serena, CL

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MonJun 16
from US$13
TueJun 17
from US$9
WedJun 18
from US$12
ThuJun 19
from US$14
FriJun 20
from US$13
SatJun 21
from US$13
SunJun 22
from US$14
MonJun 23

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 17 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: June 18 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Buses RomaniBuses Romani
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 17 at
    Departure city: Santiago
    Departure location: Santiago (Los Libertadores)
    Arrival time: June 17 at
    Destination city: La Serena
    Destination location: La Serena (Bus terminal La Serena)
    Operated by: Flixbus ChileFlixbus Chile
    Vehicle: BusDuration:
  • Departure time: June 17 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: June 17 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 17 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: June 18 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: June 17 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: June 17 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: ParaviasParavias
    Vehicle: BusDuration:

Last refresh of the prices: Today at 4:15 PM -04.

Prices and availability are subject to change.

Accepted payments

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Bus Santiago to La Serena: Trip Overview

Average Ticket PriceUS$14
Average Bus Trip Duration6h 30m
Number of daily buses63
Earliest bus departure5:50am
Distance398 km
Latest bus departure11:59pm

Santiago to La Serena Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santiago to La Serena.

We make it our job to connect you with the most dependable bus companies that cover bus service from Santiago to La Serena.

Discover how much the bus trip from Santiago to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - La Serena, CL

  1. How long is the bus ride from Santiago to La Serena?

    The bus ride from Santiago to La Serena takes 6h 30m, on average. For the shortest travel time, select the fastest bus available, which will take you to La Serena in about 5h 30m.

  2. How far is Santiago from La Serena?

    The distance between Santiago and La Serena is approximately 398 km (247 miles).

  3. What are the departure and arrival locations for buses traveling from Santiago to La Serena?

    Buses departing from Terminal Sur in Santiago will take you to Terminal de Buses La Serena in La Serena.

  4. What is the cheapest way to get from Santiago to La Serena?

    Taking the bus is the most budget-friendly option to travel from Santiago to La Serena. With a starting ticket price of US$9, this bus becomes your top pick for this journey.

  5. How much does it cost to take the bus from Santiago to La Serena?

    You can expect to pay around US$14 for the bus ride from Santiago to La Serena.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-12
US$10
06-13
US$10
Today
US$13
06-15
US$14
06-16
US$12
06-17
US$9
06-18
US$11
06-19
US$13
busbud logoThe cheapest trip from Santiago to La Serena was searched and found on Jun 17, 2025 with a price of US$9

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago to La Serena, as early as possible.

You can expect to pay from US$9 to US$34 for a bus ticket from Santiago to La Serena based on the last 2 days. You can expect to find the cheapest price for the trip at US$9 which is on 2025-06-17.

Usually Pullman San Andrés, PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santiago to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santiago to La Serena.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to La Serena will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to La Serena.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago by bus?

Bus from Santiago to La Serena

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