Next departures to Chicago
One passenger / one way
- This trip is recommended because it is the: CheapestDeparture time: June 16 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 16 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: FlixBus
Vehicle: BusDuration: - This trip is recommended because it is the: FastestDeparture time: June 16 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 16 atDestination city: ChicagoDestination location: Chicago 95Th & Dan RyanOperated by: FlixBusVehicle: BusDuration:
- Departure time: June 16 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 17 atDestination city: ChicagoDestination location: Chicago (Union Station), ILOperated by: Amtrak
Vehicle: BusDuration: - Departure time: June 16 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 16 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: June 16 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 16 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: FlixBusVehicle: BusDuration:
Last refresh of the prices: Today at 3:26 AM CDT.
Prices and availability are subject to change.
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Compare 2 ways to go from St Louis to Chicago
Busbud recommends taking the train from St Louis to ChicagoAmong the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 5 minutes, and with fares starting at just US$30, it presents an excellent value for a comfortable ride.
Bus St Louis to Chicago: Trip Overview
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St Louis to Chicago Bus
Busbud helps you find a bus from St Louis to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from St Louis to Chicago.
Whether it is cheap bus tickets or more luxurious buses going to Chicago from St Louis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in St Louis and Chicago?
Frequently asked questions on the trip St Louis - Chicago
How long is the trip from St Louis to Chicago by bus?
The typical travel time from St Louis to Chicago by bus is around 7h. For the shortest travel time, select the fastest bus available, which will take you to Chicago in about 5h 50m.
What is the travel distance from St Louis to Chicago?
The distance between St Louis and Chicago is around 419 km (260 miles).
What are the departure and arrival locations for buses traveling from St Louis to Chicago?
Buses traveling this route start their trip at Gateway Station, in St Louis, and end it at Downtown Greyhound Station, in Chicago.
How much does the bus ticket cost from St Louis to Chicago?
The bus fare from St Louis to Chicago is approximately US$51.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St Louis to Chicago was searched and found on Jun 17, 2025 with a price of US$37To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to Chicago, as early as possible.
You can expect to pay from US$37 to US$228 for a bus ticket from St Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$37 which is on 2025-06-17.
Usually Amtrak, Burlington Trailways will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St Louis and Chicago!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St Louis to Chicago.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St Louis to Chicago.
Make a music playlist for your bus ride from St Louis to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.