Bus Tickets from St. Louis to San Antonio, US

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TodaySep 4
from US$109
TomorrowSep 5
from US$90
SatSep 6
SunSep 7
from US$88
MonSep 8
TueSep 9
from US$111
WedSep 10
ThuSep 11

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: San Antonio
    Destination location: San Antonio Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: San Antonio
    Destination location: San Antonio Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc. + Valley Transit
    FlixBus + Greyhound Lines, Inc. + Valley Transit
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 5 at
    Destination city: San Antonio
    Destination location: San Antonio Bus Station
    Operated by: Greyhound Lines, Inc. + Greyhound Lines Mexico
    Greyhound Lines, Inc. + Greyhound Lines Mexico
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: San Antonio
    Destination location: San Antonio Bus Station
    Operated by: Greyhound Lines, Inc. + FlixBus + Greyhound Lines Mexico
    Greyhound Lines, Inc. + FlixBus + Greyhound Lines Mexico
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 6 at
    Destination city: San Antonio
    Destination location: San Antonio Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc. + Valley Transit
    FlixBus + Greyhound Lines, Inc. + Valley Transit
    Vehicle: BusDuration:

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Compare 2 ways to go from St. Louis to San Antonio

Bus
Average PriceUS$88 - US$282Average Duration21h 35m
32kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$112 - US$191Average Duration1d 2h
116kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to San Antonio

Among the sustainable travel choices, the bus stands out as a good way to reach San Antonio. The journey takes about 21 hours 35 minutes, and with fares starting at just US$88, it presents an excellent value for a comfortable ride.

7bus per day
21h 35mAverage Duration
US$88Cheapest ticket
32kgCO₂ emissions

Bus St. Louis to San Antonio, US: Trip Overview

Average Ticket PriceUS$119
Average Bus Trip Duration21h 35m
Number of daily buses7
Earliest bus departure1:15am
Distance1275 km
Latest bus departure4:30pm

St. Louis to San Antonio Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to San Antonio is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from St. Louis to San Antonio will be provided by the most trusted bus companies.

Discover how much the bus trip from St. Louis to San Antonio will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip St. Louis - San Antonio, US

  1. What is the distance between St. Louis and San Antonio?

    The distance covered from St. Louis to San Antonio is 1278 km (793 miles).

  2. What are the departure and arrival locations for buses traveling from St. Louis to San Antonio?

    Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at San Antonio Bus Station, in San Antonio.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-02
No data
09-03
US$112
Today
US$83
09-05
US$83
09-06
US$101
09-07
US$81
09-08
No data
09-09
US$105
busbud logoThe cheapest trip from St. Louis to San Antonio, US was searched and found on Sep 7, 2025 with a price of US$81

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Antonio, US, as early as possible.

You can expect to pay from US$81 to US$112 for a bus ticket from St. Louis to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$81 which is on 2025-09-07.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from St. Louis to San Antonio.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from St. Louis to San Antonio, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from St. Louis to San Antonio will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Antonio.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from St. Louis to San Antonio, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from San Antonio, US to St. Louis

You can also go to San Antonio, US by train

Train from St. Louis to San Antonio, US

Why choose Busbud?

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Popular Buses Connecting San Antonio

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