Bus Tickets from St. Louis to San Antonio, US

Next departures

Next departures for St. Louis to San Antonio on October 27
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc. + Valley Transit
Gateway Station
San Antonio Bus StationCheapestFastest
Greyhound Lines, Inc. + Greyhound Lines Mexico
Gateway Station
San Antonio Bus StationNo tags
Greyhound Lines, Inc. + Valley Transit
Gateway Station
San Antonio Bus StationNo tags
Greyhound Lines, Inc.
Gateway Station
San Antonio Bus StationNo tags

Last refresh of the prices: Today at 11:25 AM CDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from St. Louis to San Antonio

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach San Antonio. The journey takes about 22 hours 30 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.

5bus per day
22h 30mAverage Duration
791 milesDistance
32kgCO₂ emissions
Bus
Average Price$75 - $296Average Duration22h 30m
32kg CO₂e
Train
Average Price$112 - $276Average Duration1d 2h
116kg CO₂e

Bus St. Louis to San Antonio, US: Trip Overview

Average ticket price$126
Average bus trip duration22h 30m
Number of daily buses5
Earliest bus departure1:00am
Distance791 miles (1275 km)
Latest bus departure4:30pm

St. Louis to San Antonio Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to San Antonio is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from St. Louis to San Antonio will be provided by the most trusted bus companies.

Discover how much the bus trip from St. Louis to San Antonio will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip St. Louis - San Antonio, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/24
$190
10/25
$165
Today
$149
10/27
$157
10/28
$68
10/29
$77
10/30
$71
10/31
$99
busbud logoThe cheapest trip from St. Louis to San Antonio, US was searched and found on Oct 28, 2025 with a price of $68

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Antonio, US, as early as possible.

You can expect to pay from $68 to $190 for a bus ticket from St. Louis to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $68 which is on 2025-10-28.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from St. Louis to San Antonio.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from St. Louis to San Antonio, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from St. Louis to San Antonio will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Antonio.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from St. Louis to San Antonio, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from San Antonio, US to St. Louis

You can also go to San Antonio, US by train

Train from St. Louis to San Antonio, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting St. Louis

Buses Leaving from St. Louis

Buses Going to St. Louis

Popular Buses Connecting San Antonio

Buses Leaving from San Antonio

Buses Going to San Antonio