Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tampa Bus Station | Port St. Lucie (Park & Ride) | CheapestFastest | ||||
 | Bus | Tampa Bus Station | Port St. Lucie (Park & Ride) | No tags | ||||
| Bus | University of South Florida | Port St. Lucie (Park & Ride) | No tags |
Last refresh of the prices: Today at 3:32 PM EST.
Get from Tampa to Port Saint Lucie
The journey takes about 5 hours 25 minutes, and with fares starting at just $55, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Port Saint Lucie?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
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Frequently asked questions about travelling from Tampa to Port Saint Lucie by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tampa to Port Saint Lucie?
The cheapest bus tickets from Tampa to Port Saint Lucie start from $55. The average price for this route is around $82. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tampa to Port Saint Lucie?
The average bus travel time from Tampa to Port Saint Lucie is 5h 25m, covering a distance of 216 km. The quickest bus can get you there in 3h 40m and is operated by FlixBus.
Which bus companies service the Tampa to Port Saint Lucie route?
What are the earliest and latest departure times for the bus from Tampa to Port Saint Lucie?
The earliest bus departs from Tampa to Port Saint Lucie at 6:50am. And the latest bus departs at 10:35pm.
What are the CO₂ emissions for the bus trip from Tampa to Port Saint Lucie?
A bus trip from Tampa to Port Saint Lucie generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Tampa to Port Saint Lucie?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Tampa to Port Saint Lucie?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Tampa to Port Saint Lucie?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Tampa to Port Saint Lucie?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Port Saint Lucie was searched and found on Dec 3, 2025 with a price of $49To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Port Saint Lucie, as early as possible.
You can expect to pay from $49 to $151 for a bus ticket from Tampa to Port Saint Lucie based on the last 2 days. You can expect to find the cheapest price for the trip at $49 which is on 2025-12-03.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
