Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tampa Bus Station | Port St. Lucie (Park & Ride) | CheapestFastest | ||||
| Bus | University of South Florida | Port St. Lucie (Park & Ride) | No tags |
Last refresh of the prices: Yesterday at 9:42 PM EST.
Get from Tampa to Port Saint Lucie
The journey takes about 5 hours 25 minutes and with fares starting at just $39, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Port Saint Lucie?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
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Frequently asked questions about traveling from Tampa to Port Saint Lucie by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Port Saint Lucie was searched and found on Nov 27, 2025 with a price of $48To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Port Saint Lucie, as early as possible.
You can expect to pay from $48 to $97 for a bus ticket from Tampa to Port Saint Lucie based on the last 2 days. You can expect to find the cheapest price for the trip at $48 which is on 2025-11-27.
Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
