Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | San Francisco Bus Station | Chicago 95Th & Dan Ryan | Cheapest | |||||
 | San Francisco Bus Station | Downtown Greyhound Station | Fastest | |||||
 | Mission St & Fremont St | Chicago (Union Station), IL | No tags | |||||
| San Francisco Bus Station | Downtown Greyhound Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | San Francisco Bus Station | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Today at 12:32 PST.
Get from San Francisco to Chicago
The journey takes about 2 days, 15 hours 15 minutes, and with fares starting at just £123, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Francisco and Chicago?
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
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Frequently asked questions about travelling by bus from San Francisco, US to Chicago
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from San Francisco to Chicago?
The cheapest coach tickets from San Francisco to Chicago start from £123. The average price for this route is around £218. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Francisco to Chicago?
The average bus journey time from San Francisco to Chicago is 2d 15h, covering a distance of 1849 miles. The fastest bus can take you there in 2d and is operated by Greyhound.
Which bus companies service the San Francisco to Chicago route?
What is the earliest and latest departure time for the bus from San Francisco to Chicago?
The earliest bus departs from San Francisco to Chicago at 08:20. And the latest bus departs at 23:25.
What are the CO₂ emissions for the bus trip from San Francisco to Chicago?
A bus journey from San Francisco to Chicago produces an estimated 75 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from San Francisco to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.
Which company has the best Wi-Fi from San Francisco to Chicago?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from San Francisco to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Francisco to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Francisco, US to Chicago was searched and found on 6 Dec 2025 with a price of £114To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco, US to Chicago as early as possible.
You can expect to pay from £114 to £2,455 for a bus ticket from San Francisco, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £114, which is on 2025-12-06.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
