Next departures from San Luis Obispo to San Diego on 1 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures from San Luis Obispo to San Diego on 2 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures from San Luis Obispo to San Diego on 3 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
San Luis Obispo
UCSD Health La Jolla Station
CheapestFastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures from San Luis Obispo to San Diego on 4 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures from San Luis Obispo to San Diego on 5 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures from San Luis Obispo to San Diego on 6 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures from San Luis Obispo to San Diego on 7 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Last refresh of the prices: Yesterday at 22:54 PST.
Compare 2 ways to travel from San Luis Obispo to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 44 minutes and with fares starting at just £50, it presents an excellent value for a comfortable ride.
Based on 5617 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi-Fi. Amtrak ticket prices on this trip start at £56
Amtrak San Luis Obispo San Diego recent customer reviews
Based on 11481 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £27
Frequently asked questions about travelling by bus from San Luis Obispo to San Diego, CA, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from San Luis Obispo to San Diego?
The cheapest coach tickets from San Luis Obispo to San Diego start from £27. The average price for this route is around £60. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Luis Obispo to San Diego?
The average bus journey time from San Luis Obispo to San Diego is 10h 10m, covering a distance of 263 miles. The fastest bus can take you there in 8h 45m and is operated by FlixBus.
Which bus companies service the San Luis Obispo to San Diego route?
Several major bus companies operate on this route with 4 buses available per day, including services from Amtrak, FlixBus.
What is the earliest and latest departure time for the bus from San Luis Obispo to San Diego?
The earliest bus departs from San Luis Obispo to San Diego at 12:55. And the latest bus departs at 19:25.
What are the CO₂ emissions for the bus trip from San Luis Obispo to San Diego?
A bus journey from San Luis Obispo to San Diego produces an estimated 11 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from San Luis Obispo to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.
Which company has the best Wi-Fi from San Luis Obispo to San Diego?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from San Luis Obispo to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Luis Obispo to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
28/11
£53
29/11
£53
Today
£53
01/12
£53
02/12
£53
03/12
£42
04/12
£53
05/12
£53
The cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on 3 Dec 2025 with a price of £42
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US as early as possible.
You can expect to pay from £42 to £96 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at £42, which is on 2025-12-03.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.