Bus Tickets from San Luis Obispo to San Diego, CA, US

Next departures

Next departures for San Luis Obispo to San Diego on October 9
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotCheapest
FlixBus
San Luis Obispo
UCSD Health La Jolla StationFastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus StopNo tags
FlixBus
San Luis Obispo
Downtown SD (Seaport)No tags
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotNo tags

Last refresh of the prices: Today at 2:02 PM PDT.

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Compare 2 ways to go from San Luis Obispo to San Diego

Bus
Average PriceUS$31 - US$92Average Duration10h 10m
11kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$65 - US$125Average Duration8h 44m
39kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from San Luis Obispo to San Diego

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 8 hours 44 minutes, and with fares starting at just US$65, it presents an excellent value for a comfortable ride.

6train per day
8h 44mAverage Duration
US$65Cheapest ticket
39kgCO₂ emissions

Bus San Luis Obispo to San Diego, CA, US: Trip Overview

Average Ticket PriceUS$59
Average Bus Trip Duration10h 10m
Number of daily buses4
Earliest bus departure12:55pm
Distance431 km
Latest bus departure7:25pm

San Luis Obispo to San Diego Bus

With Busbud, comparing and booking tickets for a bus from San Luis Obispo to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to San Diego.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from San Luis Obispo, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Luis Obispo - San Diego, CA, US

  1. What is the distance between San Luis Obispo and San Diego?

    San Luis Obispo and San Diego are 426 km (264 miles) apart.

  2. What are the departure and arrival locations for buses traveling from San Luis Obispo to San Diego?

    Buses departing from AMTRAK Station in San Luis Obispo will take you to Mission Valley Sheraton in San Diego.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-06
US$69
10-07
US$64
Today
US$68
10-09
US$68
10-10
US$68
10-11
US$68
10-12
US$77
10-13
US$35
busbud logoThe cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on Oct 13, 2025 with a price of US$35

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US, as early as possible.

You can expect to pay from US$35 to US$123 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$35 which is on 2025-10-13.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Luis Obispo to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Luis Obispo to San Diego.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis Obispo to San Diego.

Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to San Diego while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from San Luis Obispo to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Luis Obispo by bus?

Bus from San Diego, CA, US to San Luis Obispo

You can also go to San Diego, CA, US by train

Train from San Luis Obispo to San Diego, CA, US

Why choose Busbud?

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