Next departures to San Diego
One passenger / one way
- This trip is recommended because it is the: CheapestDeparture time: June 7 atDeparture city: San Luis ObispoDeparture location: Cal Poly Vista Grande Dining ComplexArrival time: June 8 atDestination city: San DiegoDestination location: Santa Fe DepotOperated by: Amtrak
Vehicle: BusDuration: - This trip is recommended because it is the: FastestDeparture time: June 7 atDeparture city: San Luis ObispoDeparture location: AMTRAK StationArrival time: June 7 atDestination city: San DiegoDestination location: Old Town San DiegoOperated by: AmtrakVehicle: BusDuration:
- Departure time: June 7 atDeparture city: San Luis ObispoDeparture location: Cal Poly Vista Grande Dining ComplexArrival time: June 7 atDestination city: San DiegoDestination location: Santa Fe DepotOperated by: AmtrakVehicle: BusDuration:
- Departure time: June 7 atDeparture city: San Luis ObispoDeparture location: Cal Poly Vista Grande Dining ComplexArrival time: June 7 atDestination city: San DiegoDestination location: Santa Fe DepotOperated by: AmtrakVehicle: BusDuration:
Last refresh of the prices: Yesterday at 11:03 PM PDT.
Prices and availability are subject to change.
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Compare 2 ways to go from San Luis Obispo to San Diego
Busbud recommends taking the bus from San Luis Obispo to San DiegoAmong the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 10 hours, and with fares starting at just US$45, it presents an excellent value for a comfortable ride.
Bus San Luis Obispo to San Diego: Trip Overview
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San Luis Obispo to San Diego Bus
With Busbud, comparing and booking tickets for a bus from San Luis Obispo to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to San Diego.
Whether it is cheap bus tickets or more luxurious buses going to San Diego from San Luis Obispo, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in San Luis Obispo and San Diego?
Frequently asked questions on the trip San Luis Obispo - San Diego (CA), US
How long does it take to get to San Diego from San Luis Obispo by bus?
The bus ride from San Luis Obispo to San Diego takes 10h, on average. The fastest bus on this trip will get to San Diego in 9h 20m
What is the distance between San Luis Obispo and San Diego?
San Luis Obispo and San Diego are 426 km (264 miles) apart.
What are the departure and arrival locations for buses traveling from San Luis Obispo to San Diego?
Buses departing from AMTRAK Station in San Luis Obispo will take you to Mission Valley Sheraton in San Diego.
What is the cheapest way to get from San Luis Obispo to San Diego?
Taking the bus is the cheapest option to travel from San Luis Obispo to San Diego. The ticket price for this bus starts at US$45, making this your best choice for this trip.
How much is the bus from San Luis Obispo to San Diego?
The bus from San Luis Obispo to San Diego will cost you US$89, on average.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Luis Obispo to San Diego was searched and found on Jun 6, 2025 with a price of US$54To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, as early as possible.
You can expect to pay from US$54 to US$137 for a bus ticket from San Luis Obispo to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at US$68 which is on 2025-06-07.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from San Luis Obispo to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Luis Obispo to San Diego.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis Obispo to San Diego.
Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to San Diego while indulging in miles on end of beautiful scenic views.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from San Luis Obispo to San Diego?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular Buses Connecting San Luis Obispo
Buses Leaving from San Luis Obispo
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Buses Leaving from San Diego
Buses Going to San Diego
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