Bus Tickets from San Luis Obispo to San Diego, CA, US
Next departures
Next departures for San Luis Obispo to San Diego on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
Cal Poly Vista Grande Dining Complex
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
San Luis Obispo
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus Stop
No tags
San Luis Obispo
Downtown SD (Seaport)
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Next departures for San Luis Obispo to San Diego on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
Cheapest
AMTRAK Station
Old Town San Diego
Fastest
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Cal Poly Vista Grande Dining Complex
Santa Fe Depot
No tags
Last refresh of the prices: Yesterday at 9:23 PM PST.
Compare 2 ways to go from San Luis Obispo to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 8 hours 44 minutes and with fares starting at just $65, it presents an excellent value for a comfortable ride.
Based on 5599 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $72
Amtrak San Luis Obispo San Diego recent customer reviews
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from San Luis Obispo to San Diego, CA, US by bus
What is the distance between San Luis Obispo and San Diego?
The distance between the two cities is 264 miles (426 km).
What are the departure and arrival stations when taking the bus from San Luis Obispo to San Diego?
If you're headed to San Diego from San Luis Obispo, chances are that your bus will depart from AMTRAK Station and arrive at Mission Valley Sheraton. These are the primary departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are USS Midway Museum, Boat Tours in San Diego, La Jolla Cove, Botanical Building and Lily Pond and Sunset Cliffs Natural Park.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/20
$68
11/21
$68
Today
$68
11/23
$68
11/24
$68
11/25
$68
11/26
$68
11/27
$68
The cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on Nov 20, 2025 with a price of $68
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US, as early as possible.
You can expect to pay from $68 to $140 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $68 which is on 2025-11-23.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on Nov 20, 2025 with a price of $68
