Bus from Greenville, SC to St. Louis: Tickets & Schedules

Next bus departures

Next departures for Greenville to St. Louis on January 18
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
Gateway StationCheapestFastest

Last refresh of the prices: Yesterday at 12:40 AM EST.

Compare 2 ways to go from Greenville to St. Louis

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 2 hours, and with fares starting at just $177, it presents an excellent value for a comfortable ride.

2bus per day
1d 2hAverage Duration
821 kmDistance
21kgCO₂ emissions
Average Price$177 - $387Average Duration1d 2h
21kg CO₂e
Average Price$594 - $836Average Duration1d 17h
74kg CO₂e

Frequently asked questions about travelling from Greenville, SC to St. Louis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Greenville to St. Louis?

    The cheapest bus tickets from Greenville to St. Louis start from $177. The average price for this route is around $230. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Greenville to St. Louis?

    The average bus travel time from Greenville to St. Louis is 1d 2h, covering a distance of 821 km. The quickest bus can get you there in 14h 25m and is operated by FlixBus.

  3. Which bus companies service the Greenville to St. Louis route?

    Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus, Greyhound.

  4. What are the earliest and latest departure times for the bus from Greenville to St. Louis?

    The earliest bus departs from Greenville to St. Louis at 7:45pm. And the latest bus departs at 10:00pm.

  5. What are the CO₂ emissions for the bus trip from Greenville to St. Louis?

    A bus trip from Greenville to St. Louis generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

  6. What is the best bus company from Greenville to St. Louis?

    According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12050 reviews.

  7. Which bus company has the best Wi-Fi from Greenville to St. Louis?

    Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.

  8. Which bus company has the best on-time performance from Greenville to St. Louis?

    According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Greenville to St. Louis?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

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$198
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busbud logoThe cheapest trip from Greenville, SC to St. Louis was searched and found on Jan 18, 2026 with a price of $198

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to St. Louis, as early as possible.

What's the cheapest way to go from Greenville, SC to St. Louis?

busbud logoThe Bus is the cheapest travel choice for this destination

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