Find coaches from St. Louis to Greenville, SC

Next departures

Next departures from St. Louis to Greenville on 3 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		Gateway Station
    		1116 Woodruff RdCheapest
    Greyhound Lines, Inc.
      		Gateway Station
      		1116 Woodruff RdFastest
      FlixBus + Greyhound Lines, Inc.
        		Gateway Station
        		1116 Woodruff RdNo tags

        Last refresh of the prices: Yesterday at 6:01 AM CST.

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        Compare 2 ways to travel from St. Louis to Greenville

        We recommend taking the bus

        Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 17 hours 40 minutes and with fares starting at just US$85, it presents an excellent value for a comfortable ride.

        3bus per day
        17h 40mAverage duration
        821 kmDistance
        21kgCO₂ emissions
        Bus
        		Average priceUS$85 - US$228Average duration17h 40m
        21kg CO₂e
        Train
        		Average priceUS$246 - US$515Average duration1d 20h
        74kg CO₂e

        Bus St. Louis to Greenville, SC: Trip Overview

        Average ticket priceUS$132
        Average bus trip duration17h 40m
        Number of daily buses3
        Earliest bus departure01:00
        Distance820 km
        Latest bus departure23:30

        St. Louis to Greenville Bus

        With Busbud, comparing and booking tickets for a bus from St. Louis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

        We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Greenville.

        Whether it is cheap bus tickets or more luxurious buses going to Greenville from St. Louis, we help you find what you're looking for based on how much of a budget you have.

        Frequently asked questions on the trip St. Louis - Greenville, SC

        1. How much does a bus ticket from St. Louis to Greenville cost?

          The bus ticket price from St. Louis to Greenville starts at US$85. The best way to find cheap bus tickets from St. Louis to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

        2. How long is the bus ride from St. Louis to Greenville?

          The average travel time between St. Louis and Greenville is around 17h 40m, although the fastest bus will take about 15h 40m. This is the time it takes to travel the 813 km that separates the two cities.

        3. How many daily bus connections are there between St. Louis and Greenville?

          The number of buses from St. Louis to Greenville can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Greenville by comparing and selecting the bus that fits your travel style and budget on Busbud.

        4. Which bus companies travel from St. Louis to Greenville?

          When taking the bus from St. Louis to Greenville, you can travel comfortably and safely with FlixBus, Greyhound.

        Find cheapest prices for buses

        Price is for a one-way ticket for one passenger and based on past searches.

        Best price found
        01/11
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        02/11
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        Today
        US$159
        04/11
        No data
        05/11
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        06/11
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        07/11
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        08/11
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        busbud logoThe cheapest trip from St. Louis to Greenville, SC was searched and found on 03 Nov 2025 with a price of US$159

        To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Greenville, SC as early as possible.

        About Bus Travel

        Bus Travel Tips

        Meet and talk to locals at the bus stations while travelling from St. Louis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

        From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Greenville.

        Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Greenville.

        Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Greenville while indulging in miles on end of beautiful scenic views.

        Did you know?

        The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

        Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

        The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

        What's the cheapest way to go from St. Louis to Greenville, SC?

        busbud logoThe bus is the cheapest travel choice for this destination

        Will you be returning to St. Louis by bus?

        Bus from Greenville, SC to St. Louis

        You can also go to Greenville, SC by train

        Train from St. Louis to Greenville, SC

        Why choose Busbud?

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        Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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