Find coaches from Greenville, SC to St. Louis

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Today3 Aug
Tomorrow4 Aug
from US$114
Tue5 Aug
Wed6 Aug
Thu7 Aug
Fri8 Aug
Sat9 Aug
Sun10 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 4 August at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 5 August at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 4 August at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 4 August at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 4 August at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 5 August at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 5 August at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to travel from Greenville to St. Louis

Bus
Average priceUS$94 - US$262Average duration17h 5m
21kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$417 - US$417Average duration1d 17h
74kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Greenville to St. Louis

Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 17 hours 5 minutes and with fares starting at just US$94, it presents an excellent value for a comfortable ride.

3bus per day
17h 5mAverage duration
US$94Cheapest ticket
21kgCO₂ emissions

Bus Greenville, SC to St. Louis: Trip Overview

Average ticket priceUS$127
Average bus trip duration17h 5m
Number of daily buses3
Earliest bus departure08:40
Distance509 miles
Latest bus departure22:00

Greenville to St. Louis Bus

With Busbud, comparing and booking tickets for a bus from Greenville to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Greenville to St. Louis will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville, SC - St. Louis

  1. What's the distance between Greenville and St. Louis by coach?

    The distance between Greenville and St. Louis by coach is approximately 504 miles (813 km).

  2. What is the best way to go from Greenville to St. Louis without flying?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/08
US$128
02/08
No data
Today
No data
04/08
US$107
05/08
No data
06/08
No data
07/08
No data
08/08
No data
busbud logoThe cheapest trip from Greenville, SC to St. Louis was searched and found on 4 Aug 2025 with a price of US$107

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to St. Louis as early as possible.

You can expect to pay from US$107 to US$160 for a bus ticket from Greenville, SC to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$107, which is on 2025-08-04.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Greenville to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Greenville to St. Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to St. Louis.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to St. Louis.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Greenville, SC to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Greenville, SC to St. Louis

You can also go to St. Louis by train

Train from Greenville, SC to St. Louis

Why choose Busbud?

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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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