Find coaches from Greenville, SC to St. Louis

Next departures

Next departures from Greenville to St. Louis on 7 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
    		1116 Woodruff Rd
    		Gateway StationCheapestFastest
    FlixBus + Greyhound Lines, Inc.
      		1116 Woodruff Rd
      		Gateway StationNo tags

      Last refresh of the prices: Last Friday at 11:39 EDT.

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      Compare 2 ways to travel from Greenville to St. Louis

      We recommend taking the bus

      Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 1 hour 35 minutes and with fares starting at just US$110, it presents an excellent value for a comfortable ride.

      2bus per day
      1d 1hAverage duration
      509 milesDistance
      21kgCO₂ emissions
      Bus
      		Average priceUS$110 - US$269Average duration1d 1h
      21kg CO₂e
      Train
      		Average priceUS$417 - US$586Average duration1d 17h
      74kg CO₂e

      Bus Greenville, SC to St. Louis: Trip Overview

      Average ticket priceUS$142
      Average bus trip duration1d 1h
      Number of daily buses2
      Earliest bus departure13:25
      Distance509 miles
      Latest bus departure22:00

      Greenville to St. Louis Bus

      With Busbud, comparing and booking tickets for a bus from Greenville to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

      Bus service from Greenville to St. Louis will be provided by the most trusted bus companies.

      Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Greenville, we help you find what you're looking for based on how much of a budget you have.

      Frequently asked questions on the trip Greenville, SC - St. Louis

      1. What's the distance between Greenville and St. Louis by coach?

        The distance between Greenville and St. Louis by coach is approximately 504 miles (813 km).

      2. What is the best way to go from Greenville to St. Louis without flying?

        You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

      Find cheapest prices for buses

      Price is for a one-way ticket for one passenger and based on past searches.

      Best price found
      01/11
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      02/11
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      Today
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      07/11
      US$98
      08/11
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      busbud logoThe cheapest trip from Greenville, SC to St. Louis was searched and found on 7 Nov 2025 with a price of US$98

      To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to St. Louis as early as possible.

      You can expect to pay from US$98 to US$98 for a bus ticket from Greenville, SC to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$98, which is on 2025-11-07.

      About Bus Travel

      Bus Travel Tips

      Meet and talk to locals at the bus stations while travelling from Greenville to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

      Much more than a mere vehicle taking you from Greenville to St. Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

      Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to St. Louis.

      Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to St. Louis.

      Did you know?

      The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

      The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

      The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

      What's the cheapest way to go from Greenville, SC to St. Louis?

      busbud logoThe bus is the cheapest travel choice for this destination

      Will you be returning to Greenville, SC by bus?

      Bus from St. Louis to Greenville, SC

      You can also go to St. Louis by train

      Train from Greenville, SC to St. Louis

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