Bus Tickets from Santiago, CL to Antofagasta

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MonJun 16
from $35
TueJun 17
from $26
WedJun 18
from $26
ThuJun 19
from $34
FriJun 20
from $42
SatJun 21
from $33
SunJun 22
from $33
MonJun 23

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 17 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: June 18 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 17 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: June 18 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 17 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: June 18 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 17 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: June 18 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: June 17 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja
    Arrival time: June 18 at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

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Bus Santiago to Antofagasta: Trip Overview

Average ticket price$47
Average bus trip duration18h 30m
Number of daily buses35
Earliest bus departure7:00am
Distance679 miles (1094 km)
Latest bus departure11:59pm

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Santiago, CL - Antofagasta

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/12
$35
06/13
$39
Today
$35
06/15
$32
06/16
$33
06/17
$24
06/18
$24
06/19
$32
busbud logoThe cheapest trip from Santiago to Antofagasta was searched and found on Jun 18, 2025 with a price of $24

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago to Antofagasta, as early as possible.

You can expect to pay from $24 to $65 for a bus ticket from Santiago to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at $24 which is on 2025-06-18.

Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to Antofagasta will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago by bus?

Bus from Santiago to Antofagasta

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