Bus Tickets from Santiago, CL to Antofagasta

Find affordable bus tickets from Santiago, CL to Antofagasta with flexible options. Book your trip now

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TodayMay 23
from $38
TomorrowMay 24
from $38
SunMay 25
from $43
MonMay 26
from $35
TueMay 27
from $35
WedMay 28
from $35
ThuMay 29
from $35
FriMay 30
from $46

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 24 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: May 25 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 24 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: May 25 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: May 24 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: May 25 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: May 24 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: May 25 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: May 24 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja
    Arrival time: May 25 at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

Last refresh of the prices: Today at 1:43 AM -04.

Prices and availability are subject to change.

Accepted payments

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Bus Santiago to Antofagasta: Trip Overview

Average Ticket Price$66
Average Bus Trip Duration18h 30m
Number of daily buses38
Earliest bus departure7:00am
Distance1094 km
Latest bus departure11:59pm

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - Antofagasta

  1. How long is the trip from Santiago to Antofagasta by bus?

    The typical travel time from Santiago to Antofagasta by bus is around 18h 30m. For the shortest travel time, select the fastest bus available, which will take you to Antofagasta in about 17h 15m.

  2. What is the travel distance from Santiago to Antofagasta?

    The distance between Santiago and Antofagasta is around 1091 km (677 miles).

  3. What are the departure and arrival locations for buses traveling from Santiago to Antofagasta?

    Buses traveling this route start their trip at Terminal Sur, in Santiago, and end it at Terminal Antofagasta, in Antofagasta.

  4. What is the cheapest way to go from Santiago to Antofagasta?

    The least expensive option to go from Santiago to Antofagasta would be going by bus. With a starting ticket price of $35, this bus becomes your top pick for this journey.

  5. How much does the bus ticket cost from Santiago to Antofagasta?

    Taking the bus from Santiago to Antofagasta costs on average $66.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-21
$45
05-22
$34
Today
$37
05-24
$37
05-25
$54
05-26
$34
05-27
$34
05-28
$34
busbud logoThe cheapest trip from Santiago to Antofagasta was searched and found on May 26, 2025 with a price of $34

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago to Antofagasta, as early as possible.

You can expect to pay from $34 to $91 for a bus ticket from Santiago to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at $34 which is on 2025-05-26.

Usually PlussChile, Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to Antofagasta will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago by bus?

Bus from Santiago to Antofagasta

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