Bus Tickets from St. Louis to Greenville, SC

Next departures

Next departures for St. Louis to Greenville on November 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		Gateway Station
    		1116 Woodruff RdCheapest
    Greyhound Lines, Inc.
      		Gateway Station
      		1116 Woodruff RdFastest
      Greyhound Lines, Inc. + FlixBus
        		Gateway Station
        		1116 Woodruff RdNo tags
        FlixBus + Greyhound Lines, Inc.
          		Gateway Station
          		1116 Woodruff RdNo tags

          Last refresh of the prices: Today at 6:01 AM CST.

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          Compare 2 ways to go from St. Louis to Greenville

          We recommend taking the bus

          Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 17 hours 40 minutes, and with fares starting at just US$85, it presents an excellent value for a comfortable ride.

          3bus per day
          17h 40mAverage Duration
          821 kmDistance
          21kgCO₂ emissions
          Bus
          		Average PriceUS$85 - US$228Average Duration17h 40m
          21kg CO₂e
          Train
          		Average PriceUS$246 - US$515Average Duration1d 20h
          74kg CO₂e

          Bus St. Louis to Greenville, SC: Trip Overview

          Average Ticket PriceUS$132
          Average Bus Trip Duration17h 40m
          Number of daily buses3
          Earliest bus departure1:00am
          Distance820 km
          Latest bus departure11:30pm

          St. Louis to Greenville Bus

          With Busbud, comparing and booking tickets for a bus from St. Louis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

          We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Greenville.

          Whether it is cheap bus tickets or more luxurious buses going to Greenville from St. Louis, we help you find what you're looking for based on how much of a budget you have.

          Frequently asked questions on the trip St. Louis - Greenville, SC

          1. What is the distance between St. Louis and Greenville?

            St. Louis and Greenville are 813 km (504 miles) apart.

          2. What are the departure and arrival locations for buses traveling from St. Louis to Greenville?

            Buses departing from Gateway Station in St. Louis will take you to Guadalajara Supermarket Bus Stop in Greenville.

          Find cheapest prices for buses

          Price is for a one-way ticket for one passenger and based on past searches.

          Best price found
          10-31
          No data
          11-01
          No data
          Today
          No data
          11-03
          US$159
          11-04
          No data
          11-05
          No data
          11-06
          No data
          11-07
          No data
          busbud logoThe cheapest trip from St. Louis to Greenville, SC was searched and found on Nov 3, 2025 with a price of US$159

          To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Greenville, SC, as early as possible.

          You can expect to pay from US$159 to US$159 for a bus ticket from St. Louis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$159 which is on 2025-11-03.

          About Bus Travel

          Bus Travel Tips

          Meet and talk to locals at the bus stations while travelling from St. Louis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

          From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Greenville.

          Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Greenville.

          Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Greenville while indulging in miles on end of beautiful scenic views.

          Did you know?

          The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

          Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

          The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

          What's the cheapest way to go from St. Louis to Greenville, SC?

          busbud logoThe bus is the cheapest travel choice for this destination

          Will you be returning to St. Louis by bus?

          Bus from Greenville, SC to St. Louis

          You can also go to Greenville, SC by train

          Train from St. Louis to Greenville, SC

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