Bus Tickets from Chicago to Spartanburg

Next bus departures

Next departures for Chicago to Spartanburg on November 20
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
SpartanburgCheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
SpartanburgFastest
Greyhound Lines, Inc.Bus
Downtown Greyhound Station
SpartanburgNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
SpartanburgNo tags
Greyhound Lines, Inc.Bus
537-517 W. Jackson Blvd
SpartanburgNo tags

Last refresh of the prices: Yesterday at 11:07 AM CST.

Compare 2 ways to go from Chicago to Spartanburg

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Spartanburg. The journey takes about 1 day, 2 hours and with fares starting at just $110, it presents an excellent value for a comfortable ride.

9bus per day
1d 2hAverage Duration
564 milesDistance
23kgCO₂ emissions
Average Price$110 - $299Average Duration1d 2h
23kg CO₂e
Average Price$208 - $394Average Duration1d 8h
83kg CO₂e

Frequently asked questions about traveling from Chicago to Spartanburg by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/18
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11/19
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Today
$168
11/21
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11/22
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11/23
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11/24
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11/25
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busbud logoThe cheapest trip from Chicago to Spartanburg was searched and found on Nov 20, 2025 with a price of $168

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Spartanburg, as early as possible.

What's the cheapest way to go from Chicago to Spartanburg?

busbud logoThe bus is the cheapest travel choice for this destination

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