Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Detroit Bus Station | Wytheville Bus Station | No tags | ||||
| Bus | Detroit Bus Station | Wytheville Bus Station | No tags | ||||
| Bus | Detroit Bus Station | Wytheville Bus Station | No tags | ||||
| Bus | Detroit Bus Station | Wytheville Bus Station | No tags | ||||
| Bus | Detroit Bus Station | Wytheville Bus Station | No tags |
Get from Detroit to Wytheville
The journey takes about 12 hours 30 minutes and with fares starting at just $77, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Detroit, MI to Wytheville by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to Wytheville?
The cheapest bus tickets from Detroit to Wytheville start from $77. The average price for this route is around $93. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to Wytheville?
The average bus trip duration from Detroit to Wytheville is 12h 30m, covering a distance of 388 miles (626 km). The quickest bus can get you there in 12h 30m and is operated by Greyhound.
Which bus companies service the Detroit to Wytheville route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Detroit to Wytheville?
The earliest bus departs from Detroit to Wytheville at 8:15pm. And the latest bus departs at 8:15pm.
What are the CO₂ emissions for the bus trip from Detroit to Wytheville?
A bus trip from Detroit to Wytheville generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to Wytheville was searched and found on Nov 25, 2025 with a price of $119To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Wytheville, as early as possible.
