Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gainesville Bus Stop | Key Largo | No tags | ||||
FlixBus + Greyhound | Bus | Gainesville Bus Stop | Key Largo | No tags | ||||
FlixBus + Greyhound | Bus | Rosa Parks Station | Key Largo | No tags | ||||
FlixBus + Greyhound | Bus | Rosa Parks Station | Key Largo | No tags |
Get from Gainesville to Key Largo
The journey takes about 12 hours 25 minutes and with fares starting at just $88, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Gainesville, FL to Key Largo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Gainesville to Key Largo?
The cheapest bus tickets from Gainesville to Key Largo start from $88. The average price for this route is around $103. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Gainesville to Key Largo?
The average bus trip duration from Gainesville to Key Largo is 12h 25m, covering a distance of 335 miles (540 km). The quickest bus can get you there in 11h 55m and is operated by Greyhound.
Which bus companies service the Gainesville to Key Largo route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Gainesville to Key Largo?
The earliest bus departs from Gainesville to Key Largo at 12:35am. And the latest bus departs at 10:40pm.
What are the CO₂ emissions for the bus trip from Gainesville to Key Largo?
A bus trip from Gainesville to Key Largo generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Gainesville, FL to Key Largo was searched and found on Dec 13, 2025 with a price of $174To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Key Largo, as early as possible.
