Next departures for Mezcales to Guadalajara on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Nogales Av. Alvaro Obregon
Central Camionera Poniente
Cheapest
Bus
Nogales Av. Alvaro Obregon
Central Camionera Poniente
Fastest
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Next departures for Mezcales to Guadalajara on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
Cheapest
Bus
Nogales Av. Alvaro Obregon
Central Camionera Poniente
Fastest
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Next departures for Mezcales to Guadalajara on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
Cheapest
Bus
Nogales Av. Alvaro Obregon
Central Camionera Poniente
Fastest
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Next departures for Mezcales to Guadalajara on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
Cheapest
Bus
Nogales Av. Alvaro Obregon
Central Camionera Poniente
Fastest
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Next departures for Mezcales to Guadalajara on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
Cheapest
Bus
Nogales Av. Alvaro Obregon
Central Camionera Poniente
Fastest
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Bus
Nuevo Vallarta, Nayarit
Central Camionera Poniente
No tags
Last refresh of the prices: Yesterday at 11:20 AM CST.
Compare 2 ways to go from Mezcales to Guadalajara
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Guadalajara. The journey takes about 3 hours 30 minutes and with fares starting at just $13, it presents an excellent value for a comfortable ride.
Based on 259 reviews, the company was rated 2.8 stars on Busbud. Travelers were especially satisfied with the seats and the staff but often complained with the wifi. Pacifico ticket prices on this trip start at $47
Based on 736 reviews, the company was rated 3.4 stars on Busbud. Travelers were especially satisfied with the seats and the departure location but often complained with the wifi. Futura ticket prices on this trip start at $58
A good way to travel this route is with Primera Plus buses. The company offers 8 daily departures, with ticket prices starting at $48 and the shortest trip taking about 210. Primera Plus gets you where you want to go for a fair price.
Based on 160 reviews, the company was rated 3.1 stars on Busbud. Travelers were especially satisfied with the ticket access and the seats but often complained with the wifi. Chihuahuenses ticket prices on this trip start at $58
Based on 259 reviews, the company was rated 2.8 stars on Busbud. Travelers were especially satisfied with the seats and the staff but often complained with the wifi. Pacifico ticket prices on this trip start at $47
Based on 736 reviews, the company was rated 3.4 stars on Busbud. Travelers were especially satisfied with the seats and the departure location but often complained with the wifi. Futura ticket prices on this trip start at $58
Based on 160 reviews, the company was rated 3.1 stars on Busbud. Travelers were especially satisfied with the ticket access and the seats but often complained with the wifi. Chihuahuenses ticket prices on this trip start at $58
A good way to travel this route is with Norte de Sonora buses. The company offers 2 daily departures, with ticket prices starting at $51 and the shortest trip taking about 270. Norte de Sonora gets you where you want to go for a fair price.
Based on 22 reviews, the company was rated 2 stars on Busbud. Travelers were especially satisfied with the seats and the departure location but often complained with the wifi. Nayar ticket prices on this trip start at $51
Frequently asked questions about traveling from Mezcales to Guadalajara, MX by bus
What is the distance between Mezcales and Guadalajara?
Mezcales and Guadalajara are 123 miles (197 km) apart.
What are the departure and arrival stations when taking the bus from Mezcales to Guadalajara?
If you're headed to Guadalajara from Mezcales, chances are that your bus will depart from Parada de Autobuses de Mezcales and arrive at Nueva Central. These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
$48
11/22
$48
Today
$48
11/24
$48
11/25
No data
11/26
$48
11/27
$37
11/28
$48
The cheapest trip from Mezcales to Guadalajara, MX was searched and found on Nov 27, 2025 with a price of $37
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mezcales to Guadalajara, MX, as early as possible.
You can expect to pay from $37 to $51 for a bus ticket from Mezcales to Guadalajara, MX based on the last 2 days. You can expect to find the cheapest price for the trip at $37 which is on 2025-11-27.
Usually Primera Plus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Mezcales to Guadalajara, MX was searched and found on Nov 27, 2025 with a price of $37
