Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Greyhound Station | Indianapolis Northeast | Cheapest | ||||
 | Bus | Greyhound Station | Indianapolis Bus Station | Fastest | ||||
| Bus | Greyhound Station | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Greyhound Station | Downtown Transit Center | No tags | ||||
| Bus | Greyhound Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Today at 12:06 PM CST.
Get from Mobile to Indianapolis
The journey takes about 20 hours 20 minutes and with fares starting at just $135, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mobile and Indianapolis?
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Lines, Inc. Mobile Indianapolis recent customer reviews
Seats are small. Our driver never showed up for the last of our trip. 5 hour wait for a new driver.
Becky B.
Frequently asked questions about traveling from Mobile to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mobile to Indianapolis?
The cheapest bus tickets from Mobile to Indianapolis start from $135. The average price for this route is around $183. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mobile to Indianapolis?
The average bus trip duration from Mobile to Indianapolis is 20h 20m, covering a distance of 637 miles (1027 km). The quickest bus can get you there in 19h 10m and is operated by Greyhound.
Which bus companies service the Mobile to Indianapolis route?
Several major train operators operate on this route with 6 trains available per day.
What is the earliest and latest departure time for the bus from Mobile to Indianapolis?
The earliest bus departs from Mobile to Indianapolis at 12:05am. And the latest bus departs at 3:55pm.
What are the CO₂ emissions for the bus trip from Mobile to Indianapolis?
A bus trip from Mobile to Indianapolis generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mobile to Indianapolis was searched and found on Dec 27, 2025 with a price of $206To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mobile to Indianapolis, as early as possible.
You can expect to pay from $206 to $209 for a bus ticket from Mobile to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $206 which is on 2025-12-27.
