Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Orlando Panama City recent customer reviews
The journey was very pleasant, thanks to the team of experienced, helpful and caring workers. I did not like the long layover.
5 out of 5 stars
Sharon D.
My major issue was that I could not connect to the WiFi. My final arrangements for my pickup wasn't made. I was depending on the bus WiFi for that. As the bus was delayed, the layover at Tallahassee was shortened to half hour. By the time I got food I had little time to communicate with my pickup. Food was horrible. I decided final contract could still be made using the WiFi at the Panama City Terminal. But they. Had no WiFi.
2 out of 5 stars
Quasheba C.
The staff is good at some point but at others they need to improve. Also there needs to be some earlier buses to destinations like Panama City
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Jet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United StatesJet Set Express Terminal
D - Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830
E - International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA
F - Seaworld Hotels
10100 International Drive , Orlando, 32821
Stops in Panama City
A - Panama City Greyhound Bus Station
917 Harrison Ave, Panama City, FL 32401
Frequently asked questions about traveling from Orlando to Panama City, US by bus
What is the distance between Orlando and Panama City?
The distance between the two cities is 282 miles (454 km).
What are the departure and arrival stations when taking the bus from Orlando to Panama City?
If you're headed to Panama City from Orlando, chances are that your bus will depart from Orlando Bus Station and arrive at Panama City Greyhound Bus Station. These are the most popular departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Panama City?
Once in Panama City, you can start exploring the city and discover its surroundings. The top sights and things to do are Bird Watching, Jungle Land Panama, Inter-Oceanic Canal Muesum, Panama Rainforest Discovery Center and Casco Antiguo.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$113
11/18
$106
Today
$106
11/20
$130
11/21
$140
11/22
$110
11/23
$96
11/24
No data
The cheapest trip from Orlando to Panama City, US was searched and found on Nov 23, 2025 with a price of $96
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Panama City, US, as early as possible.
You can expect to pay from $96 to $140 for a bus ticket from Orlando to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at $96 which is on 2025-11-23.
The cheapest trip from Orlando to Panama City, US was searched and found on Nov 23, 2025 with a price of $96
