Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Syracuse (Regional Transportation Center) | Columbus (E Mound St) | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | 100 E Rich St | No tags | ||||
| Bus | Syracuse (Regional Transportation Center) | Columbus (E Mound St) | No tags |
Last refresh of the prices: Today at 12:40 PM EDT.
Get from Syracuse to Columbus
The journey takes about 17 hours 25 minutes and with fares starting at just CLP 80,680, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Columbus?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Columbus
- A
Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Syracuse, US to Columbus, OH by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Columbus?
The cheapest bus tickets from Syracuse to Columbus start from CLP 80,680. The average price for this route is around CLP 129,015. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Columbus?
The average bus trip duration from Syracuse to Columbus is 17h 25m, covering a distance of 413 miles (666 km). The quickest bus can get you there in 9h 40m and is operated by Greyhound.
Which bus companies service the Syracuse to Columbus route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Syracuse to Columbus?
The earliest bus departs from Syracuse to Columbus at 4:30am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Columbus?
A bus trip from Syracuse to Columbus generates an estimated 16.635575 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Columbus, OH was searched and found on May 16, 2026 with a price of CLP 123,353To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Columbus, OH, as early as possible.
You can expect to pay from CLP 123,353 to CLP 219,104 for a bus ticket from Syracuse, US to Columbus, OH based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 133,481 which is on 2026-05-17.
