How much is the bus ticket from Winston-Salem to Indianapolis?

The cheapest bus tickets from Winston-Salem to Indianapolis start from $133. The average price for this route is around $174. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Winston-Salem to Indianapolis?

The average bus trip duration from Winston-Salem to Indianapolis is 22h 40m, covering a distance of 409 miles (660 km). The quickest bus can get you there in 19h 30m and is operated by Greyhound .

Which bus companies service the Winston-Salem to Indianapolis route?

Several major train operators operate on this route with 6 trains available per day.

What is the earliest and latest departure time for the bus from Winston-Salem to Indianapolis?

The earliest bus departs from Winston-Salem to Indianapolis at 6:55am. And the latest bus departs at 6:15pm.

What are the CO₂ emissions for the bus trip from Winston-Salem to Indianapolis?

A bus trip from Winston-Salem to Indianapolis generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Bus Winston-Salem to Indianapolis from $116 | Refundable Tickets

Next bus departures

Next departures for Winston-Salem to Indianapolis on January 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	5:55pm	Winston Salem Greyhound Bus Station	22h 40m	4:35pm	Indianapolis Bus Station	Cheapest
	Bus	4:35pm	Winston Salem Greyhound Bus Station	19h 30m	12:05pm	Indianapolis Bus Station	Fastest
	Bus	6:55am	Winston Salem Greyhound Bus Station	21h 50m	4:45am	Indianapolis Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:25am	Winston Salem Greyhound Bus Station	22h	8:25am	Downtown Transit Center	No tags
	Bus	7:10am	Winston Salem Greyhound Bus Station	1d 2h	9:45am	Indianapolis Bus Station	No tags

Next departures for Winston-Salem to Indianapolis on January 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	10:25am	Winston Salem Greyhound Bus Station	22h	8:25am	Downtown Transit Center	Cheapest
	Bus	4:35pm	Winston Salem Greyhound Bus Station	19h 30m	12:05pm	Indianapolis Bus Station	Fastest
	Bus	6:55am	Winston Salem Greyhound Bus Station	21h 50m	4:45am	Indianapolis Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:55pm	Winston Salem Greyhound Bus Station	1d 3h	9:25pm	Downtown Transit Center	No tags
	Bus	7:10am	Winston Salem Greyhound Bus Station	1d 2h	9:45am	Indianapolis Bus Station	No tags

Next departures for Winston-Salem to Indianapolis on January 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:10am	Winston Salem Greyhound Bus Station	1d 2h	9:45am	Indianapolis Bus Station	Cheapest
	Bus	4:35pm	Winston Salem Greyhound Bus Station	19h 30m	12:05pm	Indianapolis Bus Station	Fastest
	Bus	6:55am	Winston Salem Greyhound Bus Station	21h 50m	4:45am	Indianapolis Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:25am	Winston Salem Greyhound Bus Station	22h	8:25am	Downtown Transit Center	No tags
	Bus	10:25am	Winston Salem Greyhound Bus Station	23h 30m	9:55am	Indianapolis Bus Station	No tags

Last refresh of the prices: Yesterday at 4:56 PM EST.

Get from Winston-Salem to Indianapolis

This route is served by bus only

The journey takes about 22 hours 40 minutes and with fares starting at just $133, it presents an excellent value for a comfortable ride.

6bus per day

22h 40mAverage Duration

409 milesDistance

16kgCO₂ emissions

Where are the popular stops in Winston-Salem and Indianapolis?

Stops in Winston-Salem

A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101
Visit page Map
B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA
Map
C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA
Map
D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
Map

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page Map

Compare bus companies

Greyhound

3.5/587,495 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Winston-Salem to Indianapolis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Winston-Salem to Indianapolis?
The cheapest bus tickets from Winston-Salem to Indianapolis start from $133. The average price for this route is around $174. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Winston-Salem to Indianapolis?
The average bus trip duration from Winston-Salem to Indianapolis is 22h 40m, covering a distance of 409 miles (660 km). The quickest bus can get you there in 19h 30m and is operated by Greyhound.
Which bus companies service the Winston-Salem to Indianapolis route?
Several major train operators operate on this route with 6 trains available per day.
What is the earliest and latest departure time for the bus from Winston-Salem to Indianapolis?
The earliest bus departs from Winston-Salem to Indianapolis at 6:55am. And the latest bus departs at 6:15pm.
What are the CO₂ emissions for the bus trip from Winston-Salem to Indianapolis?
A bus trip from Winston-Salem to Indianapolis generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/10

No data

01/11

No data

Today

No data

01/13

$142

01/14

$124

01/15

$116

01/16

No data

01/17

No data

The cheapest trip from Winston-Salem to Indianapolis was searched and found on Jan 15, 2026 with a price of $116

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Winston-Salem to Indianapolis, as early as possible.

You can expect to pay from $116 to $165 for a bus ticket from Winston-Salem to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $116 which is on 2026-01-15.