Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago 95Th & Dan Ryan | Durham Greyhound Bus Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | Durham Greyhound Bus Station | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | Durham Greyhound Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Durham Greyhound Bus Station | No tags |
Last refresh of the prices: 2025-12-07 CST.
Compare 2 ways to go from Chicago to Durham
Among the sustainable travel choices, the bus stands out as a good way to reach Durham. The journey takes about 1 day, 1 hour 50 minutes, and with fares starting at just $147, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$147 - $634 | Average Duration1d 1h | 25kg CO₂e | ||
Train | Average Price$395 - $395 | Average Duration1d 13h | 91kg CO₂e |
Where are the popular stops in Chicago and Durham?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Durham
- A515 W Pettigrew St , Durham, NC 27703
- B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA - C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA - D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA
Compare bus companies
Frequently asked questions about travelling from Chicago to Durham, NC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Durham?
The cheapest bus tickets from Chicago to Durham start from $147. The average price for this route is around $243. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Durham?
The average bus travel time from Chicago to Durham is 1d 1h, covering a distance of 999 km. The quickest bus can get you there in 1d and is operated by Greyhound.
Which bus companies service the Chicago to Durham route?
What are the earliest and latest departure times for the bus from Chicago to Durham?
The earliest bus departs from Chicago to Durham at 5:25am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Chicago to Durham?
A bus trip from Chicago to Durham generates an estimated 25 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Chicago to Durham?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Chicago to Durham?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Chicago to Durham?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Durham?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Durham, NC, US was searched and found on Dec 17, 2025 with a price of $166To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Durham, NC, US, as early as possible.
You can expect to pay from $166 to $376 for a bus ticket from Chicago to Durham, NC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $166 which is on 2025-12-17.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Chicago to Durham, NC, US?
The bus is the cheapest travel choice for this destination
