Next bus departures

Next departures for Florence to Jacksonville on August 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	5:45am	Florence, SC	5h 45m	11:30am	Jacksonville Bus Station	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	12:10pm	Bus station	18h 50m	7:00am	Jacksonville Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:55pm	Bus station	16h 5m	7:00am	Jacksonville Bus Station	No tags

Last refresh of the prices: Yesterday at 10:46 AM EDT.

Compare 2 ways to go from Florence to Jacksonville

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Jacksonville. The journey takes about 6 hours 6 minutes, and with fares starting at just MAD 619, it presents an excellent value for a comfortable ride.

1train per day

6h 6mAverage Duration

465 kmDistance

42kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceMAD 447 - MAD 1,743	Average Duration16h 5m	CO₂ emissions 12kg CO₂e
Train	Average PriceMAD 619 - MAD 5,497	Average Duration6h 6m	CO₂ emissions 42kg CO₂e

Bus stations and stops in Florence and Jacksonville

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Jacksonville

A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA
Visit page
B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA
C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207
D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA

Compare bus companies

FlixBus

3.5/515,275 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

Greyhound

3.5/588,076 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

US bus companies:FlixBus, Greyhound, Futura, Elite, Chihuahuenses, Tufesa, Adirondack Trailways

Frequently asked questions about travelling from Florence, SC, US to Jacksonville, FL by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Jacksonville?
The cheapest bus tickets from Florence to Jacksonville start from MAD 447. The average price for this route is around MAD 910. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Jacksonville?
The average bus travel time from Florence to Jacksonville is 16h 5m, covering a distance of 466 km. The quickest bus can get you there in 5h 45m and is operated by FlixBus.
Which bus companies service the Florence to Jacksonville route?
Several major bus companies operate on this route with 3 buses available per day, including services from FlixBus, Greyhound.
What are the earliest and latest departure times for the bus from Florence to Jacksonville?
The earliest bus departs from Florence to Jacksonville at 5:45am. And the latest bus departs at 4:10pm.
What are the CO₂ emissions for the bus trip from Florence to Jacksonville?
A bus trip from Florence to Jacksonville generates an estimated 11.6274 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Florence to Jacksonville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 15116 reviews.
Which bus company has the best Wi-Fi from Florence to Jacksonville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Florence to Jacksonville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Jacksonville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08-19

MAD 474

08-20

MAD 549

Today

MAD 568

08-22

MAD 502

08-23

MAD 578

08-24

No data

08-25

No data

08-26

No data

The cheapest trip from Florence, SC, US to Jacksonville, FL was searched and found on Aug 19, 2026 with a price of MAD 474

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Jacksonville, FL, as early as possible.

You can expect to pay from MAD 474 to MAD 578 for a bus ticket from Florence, SC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 502 which is on 2026-08-22.