Next bus departures

Next departures for Florence to Jacksonville on August 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	5:45am	Florence, SC	5h 45m	11:30am	Jacksonville Bus Station	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	12:10pm	Bus station	18h 50m	7:00am	Jacksonville Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:55pm	Bus station	16h 5m	7:00am	Jacksonville Bus Station	No tags

Last refresh of the prices: Last Thursday at 8:35 AM EDT.

Compare 2 ways to go from Florence to Jacksonville

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Jacksonville. The journey takes about 6 hours 6 minutes and with fares starting at just ₪201, it presents an excellent value for a comfortable ride.

1train per day

6h 6mAverage Duration

289 milesDistance

42kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price₪145 - ₪564	Average Duration16h 5m	CO₂ emissions 12kg CO₂e
Train	Average Price₪201 - ₪1,779	Average Duration6h 6m	CO₂ emissions 42kg CO₂e

Bus stations and stops in Florence and Jacksonville

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Jacksonville

A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA
Visit page
B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA
C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207
D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA

Compare bus companies

FlixBus

3.5/515,293 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/588,078 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, Greyhound, Futura, Chihuahuenses, Tufesa, Elite, Adirondack Trailways

Frequently asked questions about traveling from Florence, SC, US to Jacksonville, FL by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Jacksonville?
The cheapest bus tickets from Florence to Jacksonville start from ₪145. The average price for this route is around ₪295. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Jacksonville?
The average bus trip duration from Florence to Jacksonville is 16h 5m, covering a distance of 289 miles (466 km). The quickest bus can get you there in 5h 45m and is operated by FlixBus.
Which bus companies service the Florence to Jacksonville route?
Several major bus companies operate on this route with 3 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Florence to Jacksonville?
The earliest bus departs from Florence to Jacksonville at 5:45am. And the latest bus departs at 4:10pm.
What are the CO₂ emissions for the bus trip from Florence to Jacksonville?
A bus trip from Florence to Jacksonville generates an estimated 11.6274 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Jacksonville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 15116 reviews.
Which bus company has the best Wi-Fi from Florence to Jacksonville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Jacksonville?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Jacksonville?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08/20

₪178

08/21

₪184

Today

₪163

08/23

₪187

08/24

No data

08/25

No data

08/26

No data

08/27

No data

The cheapest trip from Florence, SC, US to Jacksonville, FL was searched and found on Aug 22, 2026 with a price of ₪163

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Jacksonville, FL, as early as possible.

You can expect to pay from ₪163 to ₪187 for a bus ticket from Florence, SC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at ₪187 which is on 2026-08-23.