Next departures to St. Louis
One passenger / one way
- This trip is recommended because it is the: Cheapest + FastestDeparture time: July 14 atDeparture city: IndianapolisDeparture location: Indianapolis Bus StationArrival time: July 14 atDestination city: St. LouisDestination location: Gateway StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: July 14 atDeparture city: IndianapolisDeparture location: Greyhound Amtrak StationArrival time: July 14 atDestination city: St. LouisDestination location: Gateway StationOperated by: Amtrak
Vehicle: BusDuration: - Departure time: July 14 atDeparture city: IndianapolisDeparture location: Indianapolis Bus StationArrival time: July 14 atDestination city: St. LouisDestination location: Gateway StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: July 14 atDeparture city: IndianapolisDeparture location: Greyhound Amtrak StationArrival time: July 14 atDestination city: St. LouisDestination location: Gateway StationOperated by: AmtrakVehicle: BusDuration:
- Departure time: July 14 atDeparture city: IndianapolisDeparture location: Indianapolis Bus StationArrival time: July 14 atDestination city: St. LouisDestination location: Gateway StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
Last refresh of the prices: Last Friday at 12:42 PM EDT.
Prices and availability are subject to change.
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Compare 2 ways to go from Indianapolis to St. Louis
Busbud recommends taking the bus from Indianapolis to St. LouisAmong the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 4 hours 30 minutes, and with fares starting at just US$42, it presents an excellent value for a comfortable ride.
Bus Indianapolis to St. Louis: Trip Overview
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Indianapolis to St. Louis Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Indianapolis to St. Louis.
We make sure you can find a bus service from Indianapolis to St. Louis from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Indianapolis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Indianapolis and St. Louis?
Frequently asked questions on the trip Indianapolis - St. Louis
What is the distance between Indianapolis and St. Louis?
The distance between Indianapolis and St. Louis is approximately 371 km (230 miles).
What are the departure and arrival locations for buses traveling from Indianapolis to St. Louis?
Buses departing from Greyhound Amtrak Station in Indianapolis will take you to Gateway Station in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to St. Louis was searched and found on Jul 14, 2025 with a price of US$34To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to St. Louis, as early as possible.
You can expect to pay from US$34 to US$236 for a bus ticket from Indianapolis to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$34 which is on 2025-07-14.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Indianapolis to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to St. Louis, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to St. Louis.
Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to St. Louis while indulging in miles on end of beautiful scenic views.
Did you know?
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
What's the cheapest way to go from Indianapolis to St. Louis?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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