Next departures for Indianapolis to St. Louis on November 23
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Vehicle type
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Recommended
Price and booking link
Indianapolis Bus Station
Gateway Station
CheapestFastest
Greyhound Amtrak Station
Gateway Station
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Indianapolis Bus Station
Gateway Station
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Greyhound Amtrak Station
Gateway Station
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Indianapolis Bus Station
Gateway Station
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Next departures for Indianapolis to St. Louis on November 24
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Price and booking link
Indianapolis Bus Station
Gateway Station
CheapestFastest
Greyhound Amtrak Station
Gateway Station
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Indianapolis Bus Station
Gateway Station
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Greyhound Amtrak Station
Gateway Station
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Indianapolis Bus Station
Gateway Station
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Next departures for Indianapolis to St. Louis on November 25
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Vehicle type
Departure time
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Recommended
Price and booking link
Indianapolis Bus Station
Gateway Station
CheapestFastest
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
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Greyhound Amtrak Station
Gateway Station
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Indianapolis Bus Station
Gateway Station
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Next departures for Indianapolis to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Indianapolis Bus Station
Gateway Station
CheapestFastest
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
No tags
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
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Next departures for Indianapolis to St. Louis on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Indianapolis Bus Station
Gateway Station
CheapestFastest
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
No tags
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
No tags
Next departures for Indianapolis to St. Louis on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Indianapolis Bus Station
Gateway Station
CheapestFastest
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
No tags
Greyhound Amtrak Station
Gateway Station
No tags
Indianapolis Bus Station
Gateway Station
No tags
Last refresh of the prices: Yesterday at 3:20 PM EST.
Compare 2 ways to go from Indianapolis to St. Louis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 4 hours 20 minutes and with fares starting at just $42, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Indianapolis St. Louis recent customer reviews
The bus had some problems. Air conditioning was malfunctioning, and none of the outlets worked. There was also considerable damage to the seats that should have been repaired. The counter clerk was very friendly and helpful, but the bus driver seemed to be in a very bad mood and possibly ill, loudly coughing up phlegm the entire trip, and he gave us no indication of how late the bus was going to arrive. I will not ride Greyhound again if I can possibly avoid it.
2 out of 5 stars
Tremain X.
The 3:15 bus never arrived so I was forced to wait 6 hours at the station for the next departure. This was very poorly communicated to passengers and no effort was made for any sort of reimbursement. I will absolutely never use Greyhound again.
Based on 5597 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $79
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $193
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Indianapolis to St. Louis by bus
What is the distance between Indianapolis and St. Louis?
Indianapolis and St. Louis are 230 miles (371 km) apart.
What are the departure and arrival stations when taking the bus from Indianapolis to St. Louis?
Buses going from Indianapolis to St. Louis begin their journey at Greyhound Amtrak Station and reach their destination at Gateway Station.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Powell Symphony Hall, Old St. Louis County Courthouse, Municipal Theatre Association, St. Louis Cardinals and Anheuser-Busch Brewery.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$55
11/20
$84
Today
$60
11/22
$60
11/23
$55
11/24
$56
11/25
$62
11/26
$62
The cheapest trip from Indianapolis to St. Louis was searched and found on Nov 19, 2025 with a price of $55
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to St. Louis, as early as possible.
You can expect to pay from $55 to $172 for a bus ticket from Indianapolis to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $55 which is on 2025-11-23.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Indianapolis to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Indianapolis to St. Louis was searched and found on Nov 19, 2025 with a price of $55
The bus is the cheapest travel choice for this destination
