Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Pittsburgh Intermodal Station | Des Moines | Cheapest | ||||
 | Bus | Pittsburgh Intermodal Station | Des Moines | Fastest |
Last refresh of the prices: Today at 3:35 AM EST.
Get from Pittsburgh to Des Moines
The journey takes about 23 hours 50 minutes, and with fares starting at just $215, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Des Moines?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Compare bus companies
Based on 87456 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $232
Frequently asked questions about travelling from Pittsburgh to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pittsburgh to Des Moines?
The cheapest bus tickets from Pittsburgh to Des Moines start from $215. The average price for this route is around $288. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to Des Moines?
The average bus travel time from Pittsburgh to Des Moines is 23h 50m, covering a distance of 1148 km. The quickest bus can get you there in 18h 55m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Des Moines route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Pittsburgh to Des Moines?
The earliest bus departs from Pittsburgh to Des Moines at 12:40am. And the latest bus departs at 7:45pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to Des Moines?
A bus trip from Pittsburgh to Des Moines generates an estimated 29 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Des Moines was searched and found on Dec 31, 2025 with a price of $191To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Des Moines, as early as possible.
You can expect to pay from $191 to $406 for a bus ticket from Pittsburgh to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $191 which is on 2025-12-31.
