Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Pittsburgh Intermodal Station | Des Moines | Cheapest | ||||
 | Bus | Pittsburgh Intermodal Station | Des Moines | Fastest |
Last refresh of the prices: Today at 3:35 AM EST.
Get from Pittsburgh to Des Moines
The journey takes about 23 hours 50 minutes and with fares starting at just $154, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pittsburgh and Des Moines?
Stops in Pittsburgh
- A55 11th St, Pittsburgh, PA 15222, USA
- B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Pittsburgh to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pittsburgh to Des Moines?
The cheapest bus tickets from Pittsburgh to Des Moines start from $154. The average price for this route is around $206. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to Des Moines?
The average bus trip duration from Pittsburgh to Des Moines is 23h 50m, covering a distance of 712 miles (1148 km). The quickest bus can get you there in 18h 55m and is operated by Greyhound.
Which bus companies service the Pittsburgh to Des Moines route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Pittsburgh to Des Moines?
The earliest bus departs from Pittsburgh to Des Moines at 12:40am. And the latest bus departs at 7:45pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to Des Moines?
A bus trip from Pittsburgh to Des Moines generates an estimated 29 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Des Moines was searched and found on Dec 31, 2025 with a price of $136To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Des Moines, as early as possible.
You can expect to pay from $136 to $289 for a bus ticket from Pittsburgh to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at $136 which is on 2025-12-31.
Top traveled bus routes
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