Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Greyhound Bus Stop | San Antonio Bus Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | UCSD Health La Jolla Station | San Antonio Bus Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. + Greyhound Lines Mexico | Bus | San Diego (Old Town-FlixBus) | San Antonio Bus Station | No tags | ||||
Greyhound Lines, Inc. + Valley Transit | Bus | Greyhound Bus Stop | San Antonio Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | San Antonio Bus Station | No tags |
Last refresh of the prices: Yesterday at 5:46 PM PST.
Compare 2 ways to go from San Diego to San Antonio
Among the sustainable travel choices, the train stands out as a good way to reach San Antonio. The journey takes about 1 day, 10 hours 50 minutes, and with fares starting at just $382, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and San Antonio?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in San Antonio
- A500 N St Mary's St, San Antonio, TX 78205, USA
- B7914 Interstate 35 Access Rd, San Antonio, TX 78224, USA
- C165 Bowie St, San Antonio, 78205
- D4407 S PanAm Expy #101, San Antonio, TX 78225, USA
Compare bus companies
Frequently asked questions about travelling from San Diego, CA, US to San Antonio, US by bus
What is the distance between San Diego and San Antonio?
The distance between San Diego and San Antonio is around 1815 km (1125 miles).
What are the departure and arrival locations for buses traveling from San Diego to San Antonio?
Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at San Antonio Bus Station, in San Antonio.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to San Antonio, US was searched and found on Nov 25, 2025 with a price of $327To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to San Antonio, US, as early as possible.
You can expect to pay from $327 to $327 for a bus ticket from San Diego, CA, US to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $327 which is on 2025-11-25.
What's the cheapest way to go from San Diego, CA, US to San Antonio, US?
The bus is the cheapest travel choice for this destination
