Bus Tickets from La Serena, CL to Antofagasta

Find affordable bus tickets from La Serena, CL to Antofagasta with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJun 5
from US$21
TomorrowJun 6
from US$21
SatJun 7
from US$21
SunJun 8
from US$36
MonJun 9
from US$21
TueJun 10
WedJun 11
ThuJun 12

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 6 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: June 6 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 6 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: June 7 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: June 7 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: June 7 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: June 7 at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 9:21 PM -04.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus La Serena to Antofagasta: Trip Overview

Average Ticket PriceUS$41
Average Bus Trip Duration11h 35m
Number of daily buses33
Earliest bus departure12:05am
Distance705 km
Latest bus departure11:59pm

La Serena to Antofagasta Bus

Busbud helps you find a bus from La Serena to Antofagasta. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from La Serena to Antofagasta will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Antofagasta from La Serena, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip La Serena, CL - Antofagasta

  1. How long is the bus trip from La Serena to Antofagasta?

    The trip from La Serena to Antofagasta will take on average 11h 35m. The fastest bus on this trip will get to Antofagasta in 10h 40m

  2. How far is La Serena from Antofagasta?

    The distance covered from La Serena to Antofagasta is 704 km (437 miles).

  3. What are the departure and arrival locations for buses traveling from La Serena to Antofagasta?

    Buses traveling this route start their trip at Terminal de Buses La Serena, in La Serena, and end it at Terminal Antofagasta, in Antofagasta.

  4. What is the cheapest way to go from La Serena to Antofagasta?

    If you're on a budget, consider traveling by bus to Antofagasta from La Serena; it tends to be more affordable. The ticket price for this bus starts at US$21, making this your best choice for this trip.

  5. How much does it cost to take the bus from La Serena to Antofagasta?

    The bus fare from La Serena to Antofagasta is approximately US$41.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-03
US$28
06-04
US$33
Today
US$20
06-06
US$20
06-07
US$20
06-08
US$33
06-09
US$20
06-10
US$20
busbud logoThe cheapest trip from La Serena to Antofagasta was searched and found on Jun 10, 2025 with a price of US$20

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Antofagasta, as early as possible.

You can expect to pay from US$20 to US$53 for a bus ticket from La Serena to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$20 which is on 2025-06-10.

Usually Buses Andimar, PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Serena and Antofagasta!

Much more than a mere vehicle taking you from La Serena to Antofagasta, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Serena to Antofagasta.

Make a music playlist for your bus ride from La Serena to Antofagasta, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to La Serena by bus?

Bus from La Serena to Antofagasta

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting La Serena

Buses Leaving from La Serena

Buses Going to La Serena

Popular Buses Connecting Antofagasta

Buses Leaving from Antofagasta

Buses Going to Antofagasta