Bus Tickets from Wilmington, DE to Wytheville

Next departures

Next departures for Wilmington to Wytheville on November 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
    		Wilmington Bus Station
    		Wytheville Bus StationCheapestFastest

    Last refresh of the prices: Yesterday at 8:41 AM EST.

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    Get from Wilmington to Wytheville

    This route is served by bus only

    The journey takes about 16 hours 35 minutes, and with fares starting at just $85, it presents an excellent value for a comfortable ride.

    4bus per day
    16h 35mAverage Duration
    541 kmDistance
    14kgCO₂ emissions

    Bus Wilmington, DE to Wytheville: Trip Overview

    Average Ticket Price$113
    Average Bus Trip Duration16h 35m
    Number of daily buses4
    Earliest bus departure2:50am
    Distance541 km
    Latest bus departure9:25pm

    Wilmington to Wytheville Bus

    Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Wilmington to Wytheville.

    We make it our job to connect you with the most dependable bus companies that cover bus service from Wilmington to Wytheville.

    Discover how much the bus trip from Wilmington to Wytheville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

    Frequently asked questions on the trip Wilmington, DE - Wytheville

    1. What is the distance between Wilmington and Wytheville?

      The distance between Wilmington and Wytheville is around 574 km (356 miles).

    Find cheapest prices for buses

    Price is for a one-way ticket for one passenger and based on past searches.

    Best price found
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    $139
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    busbud logoThe cheapest trip from Wilmington, DE to Wytheville was searched and found on Nov 4, 2025 with a price of $139

    To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Wytheville, as early as possible.

    About Bus Travel

    Bus Travel Tips

    If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Wilmington to Wytheville but it'll also be endearing to native speakers who will surely appreciate your effort.

    From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Wilmington to Wytheville.

    Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Wilmington to Wytheville will emit less CO2 than a car or an airplane.

    Tune out to the fine sounds of your best music playlist on your bus trip from Wilmington to Wytheville while indulging in miles on end of beautiful scenic views.

    Did you know?

    9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

    One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

    It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

    Will you be returning to Wilmington, DE by bus?

    Bus from Wytheville to Wilmington, DE

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