Find coaches from Greenville (SC) to St Louis

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Tomorrow26 May
from US$144
Tue27 May
Wed28 May
Thu29 May
Fri30 May
Sat31 May
Sun1 Jun
Mon2 Jun

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 26 May at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 27 May at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 26 May at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 26 May at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 26 May at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 26 May at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 26 May at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 27 May at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 26 May at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: 27 May at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from Greenville to St Louis

Average priceUS$82 - US$132Average duration16h 20m
21kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Average priceUS$417 - US$417Average duration1d 17h
74kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Greenville to St Louis

Among the sustainable travel choices, the bus stands out as a good way to reach St Louis. The journey takes about 16 hours 20 minutes and with fares starting at just US$82, it presents an excellent value for a comfortable ride.

4bus per day
16h 20mAverage duration
US$82Cheapest ticket
21kgCO₂ emissions

Bus Greenville to St Louis: Trip Overview

Average ticket priceUS$90
Average bus trip duration16h 20m
Number of daily buses4
Earliest bus departure08:45
Distance509 miles
Latest bus departure22:00

Greenville to St Louis Bus

With Busbud, comparing and booking tickets for a bus from Greenville to St Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Greenville to St Louis will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to St Louis from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville (SC) - St Louis

  1. How much does it cost to go to St Louis by bus?

    For coach travel from Greenville to St Louis, ticket prices typically start at US$82 and can reach a maximum of US$132. The exact cost can vary based on different factors such as the time of travel, the day of the week, and the coach service provider. Compare the prices and amenities offered by each company on Busbud and find the best deals and offers.

  2. How long is a coach from Greenville to St Louis?

    The average duration for a trip from Greenville to St Louis by coach is around 16h 20m. If you're looking for the fastest trip, you can get there in just about 14h 15m. However, please keep in mind that your specific travel time may vary due to the prevailing traffic conditions along the route.

  3. At what time is the first coach from Greenville to St Louis?

    The first coach to St Louis from Greenville departs at 08:45. Times and services may vary during weekends and holidays.

  4. What's the distance between Greenville and St Louis by coach?

    The distance between Greenville and St Louis by coach is approximately 504 miles (813 km).

  5. What is the best way to go from Greenville to St Louis without flying?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

  6. Can I catch a night coach from Greenville to St Louis?

    You can hop on buses departing from Greenville until 22:00 and reaching St Louis the following day. Make sure to bring a snack and a blanket to keep yourself feeling comfortable during the night.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
23/05
No data
24/05
No data
Today
No data
26/05
US$139
27/05
No data
28/05
No data
29/05
No data
30/05
No data
busbud logoThe cheapest trip from Greenville to St Louis was searched and found on 26 May 2025 with a price of US$139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville to St Louis as early as possible.

You can expect to pay from US$139 to US$145 for a bus ticket from Greenville to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$139, which is on 2025-05-26.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Greenville to St Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Greenville to St Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to St Louis.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to St Louis.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Greenville to St Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville by bus?

Bus from Greenville to St Louis

You can also go to St Louis by train

Train from Greenville to St Louis

Why choose Busbud?

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