Find coaches from Santa Bárbara (Biobio Region), CL to Santiago, CL

Find affordable coach tickets from Santa Bárbara (Biobio Region), CL to Santiago, CL with flexible options. Book your journey now

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Sat14 Jun
Sun15 Jun
Mon16 Jun
from US$14
Tue17 Jun
Wed18 Jun
Thu19 Jun
Fri20 Jun
Sat21 Jun

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 16 June at
    Departure city: Santa Bárbara
    Departure location: Santa Bárbara
    Arrival time: 17 June at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • Departure time: 16 June at
    Departure city: Santa Bárbara
    Departure location: Santa Bárbara
    Arrival time: 16 June at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • Departure time: 16 June at
    Departure city: Santa Bárbara
    Departure location: Santa Bárbara
    Arrival time: 16 June at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • Departure time: 16 June at
    Departure city: Santa Bárbara
    Departure location: Santa Bárbara
    Arrival time: 17 June at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:
  • Departure time: 16 June at
    Departure city: Santa Bárbara
    Departure location: Santa Bárbara
    Arrival time: 16 June at
    Destination city: Santiago
    Destination location: Terminal Sur
    Operated by: EME BusEME Bus
    Vehicle: BusDuration:

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Bus Santa Bárbara to Santiago: Trip Overview

Average ticket priceUS$15
Average bus trip duration5h 53m
Number of daily buses2
Earliest bus departure05:50
Distance300 miles
Latest bus departure21:50

Santa Bárbara to Santiago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Bárbara to Santiago.

Bus service from Santa Bárbara to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Santa Bárbara to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Santa Bárbara (Biobio Region), CL - Santiago, CL

  1. How much does a coach ticket from Santa Bárbara to Santiago cost?

    Coach ticket prices from Santa Bárbara to Santiago can start as low as US$14, though the average price for this trip is US$15. These prices can change depending on factors like the date, the class and the coach company you choose. Compare the prices and amenities offered by each company on Busbud and find the best deals and offers.

  2. How long does the coach from Santa Bárbara to Santiago take?

    The coach journey between Santa Bárbara and Santiago lasts about 5h 53m. The quickest coach journey typically takes 5h 53m. Please be aware that the time it takes for your journey may vary depending on the traffic conditions along the route.

  3. At what time does the first coach from Santa Bárbara to Santiago leave?

    The first coach from Santa Bárbara to Santiago leaves at 05:50. Keep in mind that departure times might change on weekends and holidays.

  4. What's the distance between Santa Bárbara and Santiago by coach?

    The journey from Santa Bárbara to Santiago by coach covers an approximate distance of 304 miles (490 km).

  5. How can I travel from Santa Bárbara to Santiago avoiding air travel?

    To travel from Santa Bárbara to Santiago without flying, you can take the coaches. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/06
No data
11/06
US$13
Today
US$13
13/06
US$14
14/06
No data
15/06
No data
16/06
US$13
17/06
No data
busbud logoThe cheapest trip from Santa Bárbara to Santiago was searched and found on 12 Jun 2025 with a price of US$13

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Bárbara to Santiago as early as possible.

You can expect to pay from US$13 to US$26 for a bus ticket from Santa Bárbara to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$13, which is on 2025-06-16.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Bárbara to Santiago but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Santa Bárbara to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santa Bárbara to Santiago that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santa Bárbara to Santiago.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Santa Bárbara by bus?

Bus from Santa Bárbara to Santiago

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