Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 4565 Gaynor Ave, North Charleston | Downtown Greyhound Station | No tags | ||||
| Bus | 4565 Gaynor Ave, North Charleston | Chicago 95Th & Dan Ryan | No tags | ||||
| Bus | 4565 Gaynor Ave, North Charleston | 537-517 W. Jackson Blvd | No tags | ||||
FlixBus + Greyhound | Bus | 4565 Gaynor Ave, North Charleston | Chicago 95Th & Dan Ryan | No tags | ||||
FlixBus + Greyhound | Bus | 4565 Gaynor Ave, North Charleston | Downtown Greyhound Station | No tags |
Compare 2 ways to go from Charleston to Chicago
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 5 hours 40 minutes and with fares starting at just $106, it presents an excellent value for a comfortable ride.
Where are the popular stops in Charleston and Chicago?
Stops in Charleston
- A
Charleston Bus Station
3610 Dorchester Rd, North Charleston, SC 29405
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Charleston, SC, US to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Charleston to Chicago?
The cheapest bus tickets from Charleston to Chicago start from $106. The average price for this route is around $153. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Charleston to Chicago?
The average bus trip duration from Charleston to Chicago is 1d 5h, covering a distance of 748 miles (1207 km). The quickest bus can get you there in 1d 5h and is operated by Greyhound.
Which bus companies service the Charleston to Chicago route?
Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Charleston to Chicago?
The earliest bus departs from Charleston to Chicago at 11:15am. And the latest bus departs at 11:15am.
What are the CO₂ emissions for the bus trip from Charleston to Chicago?
A bus trip from Charleston to Chicago generates an estimated 30 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Charleston to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Charleston to Chicago?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Charleston to Chicago?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Charleston to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Charleston, SC, US to Chicago was searched and found on Jan 1, 2026 with a price of $245To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to Chicago, as early as possible.
What's the cheapest way to go from Charleston, SC, US to Chicago?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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