Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Cincinnati Bus Station | 1116 Woodruff Rd | No tags | ||||
Greyhound + FlixBus | Bus | Cincinnati Bus Station | 1116 Woodruff Rd | No tags | ||||
 | Bus | Cincinnati (Downtown) | 1116 Woodruff Rd | No tags | ||||
| Bus | Cincinnati Bus Station | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound | Bus | Cincinnati Bus Station | 1116 Woodruff Rd | No tags |
Compare 2 ways to go from Cincinnati to Greenville
Among the sustainable travel choices, the Bus stands out as the good way to reach Greenville. The journey takes about 19 hours and with fares starting at just $90, it presents an excellent value for a comfortable ride.
Where are the popular stops in Cincinnati and Greenville?
Stops in Cincinnati
- A1005 Gilbert Ave, Cincinnati, OH 45202
- B
Northland Blvd
290-322 Northland Blvd, Springdale, OH 45246, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Cincinnati to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Cincinnati to Greenville?
The cheapest bus tickets from Cincinnati to Greenville start from $90. The average price for this route is around $164. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Cincinnati to Greenville?
The average bus trip duration from Cincinnati to Greenville is 19h, covering a distance of 325 miles (524 km). The quickest bus can get you there in 17h 10m and is operated by Greyhound.
Which bus companies service the Cincinnati to Greenville route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Cincinnati to Greenville?
The earliest bus departs from Cincinnati to Greenville at 12:55am. And the latest bus departs at 5:30pm.
What are the CO₂ emissions for the bus trip from Cincinnati to Greenville?
A bus trip from Cincinnati to Greenville generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Cincinnati to Greenville, SC was searched and found on Jan 17, 2026 with a price of $97To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Cincinnati to Greenville, SC, as early as possible.
What's the cheapest way to go from Cincinnati to Greenville, SC?
The Bus is the cheapest travel choice for this destinationTop traveled bus routes
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