What is the distance between Cincinnati and Knoxville?

The distance between the two cities is 223 miles (360 km).

What are the departure and arrival stations when taking the bus from Cincinnati to Knoxville?

If you're headed to Knoxville from Cincinnati, chances are that your bus will depart from Greyhound Station and arrive at 100 Kirkwood St. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

Bus Cincinnati to Knoxville from $35 | Refundable Tickets

Next bus departures

Next departures for Cincinnati to Knoxville on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	1:20pm	Cincinnati Bus Station	5h 35m	6:55pm	Knoxville Bus Station	CheapestFastest

Last refresh of the prices: Last Friday at 9:43 PM EST.

Get from Cincinnati to Knoxville

This route is served by bus only

The journey takes about 5 hours 35 minutes and with fares starting at just $43, it presents an excellent value for a comfortable ride.

1bus per day

5h 35mAverage Duration

224 milesDistance

9kgCO₂ emissions

Where are the popular stops in Cincinnati and Knoxville?

Stops in Cincinnati

A
Greyhound Station
1005 Gilbert Ave, Cincinnati, OH 45202
Visit page
B
Northland Blvd
290-322 Northland Blvd, Springdale, OH 45246, USA

Stops in Knoxville

A
100 Kirkwood St
Knoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Visit page

Compare bus companies

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Cincinnati Knoxville recent customer reviews

30 minute delay plus air conditioner was broken on bus very uncomfortable for my very first bus ride

Jaicelyn T.

July 14, 2017

Driver was a substitute for absent driver and very apprehensive about anyone approaching or talking with a moderate decibel. Bus felt like the The front was shaking due to an unbalanced tire. When inquiring with the bus driver he said he had to leave the resistant break on from the time we left Lexington until Knoxville

Michael N.

April 22, 2017

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Cincinnati to Knoxville, TN by bus

What is the distance between Cincinnati and Knoxville?
What are the departure and arrival stations when taking the bus from Cincinnati to Knoxville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/21

$46

11/22

$72

Today

$74

11/24

$58

11/25

$52

11/26

$53

11/27

$49

11/28

$49

The cheapest trip from Cincinnati to Knoxville, TN was searched and found on Nov 21, 2025 with a price of $46

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Cincinnati to Knoxville, TN, as early as possible.

You can expect to pay from $46 to $74 for a bus ticket from Cincinnati to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $49 which is on 2025-11-27.