Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Cleveland Bus Station | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound | Bus | Cleveland Bus Station | 1116 Woodruff Rd | No tags | ||||
Greyhound + FlixBus | Bus | Cleveland Bus Station | 1116 Woodruff Rd | No tags | ||||
 | Bus | Cleveland Bus Station | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound | Bus | Cleveland Bus Station | 1116 Woodruff Rd | No tags |
Compare 2 ways to go from Cleveland to Greenville
Among the sustainable travel choices, the Bus stands out as the good way to reach Greenville. The journey takes about 21 hours 45 minutes and with fares starting at just $103, it presents an excellent value for a comfortable ride.
Where are the popular stops in Cleveland and Greenville?
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Cleveland, OH, US to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Cleveland to Greenville?
The cheapest bus tickets from Cleveland to Greenville start from $103. The average price for this route is around $184. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Cleveland to Greenville?
The average bus trip duration from Cleveland to Greenville is 21h 45m, covering a distance of 462 miles (745 km). The quickest bus can get you there in 21h 45m and is operated by Greyhound.
Which bus companies service the Cleveland to Greenville route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Cleveland to Greenville?
The earliest bus departs from Cleveland to Greenville at 2:35am. And the latest bus departs at 4:50pm.
What are the CO₂ emissions for the bus trip from Cleveland to Greenville?
A bus trip from Cleveland to Greenville generates an estimated 19 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Cleveland, OH, US to Greenville, SC was searched and found on Jan 15, 2026 with a price of $92To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Cleveland, OH, US to Greenville, SC, as early as possible.
What's the cheapest way to go from Cleveland, OH, US to Greenville, SC?
The Bus is the cheapest travel choice for this destination
