Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Estación Juárez Parada de Autobuses | Santa Ana | Cheapest | ||||
 | Bus | Zapopan Central de Autobuses (Guadalajara) | Santa Ana Col Del Rio | Fastest | ||||
| Bus | Nueva Central | Santa Ana Col Del Rio | No tags | ||||
| Bus | Zapopan Guadalajara | Santa Ana | No tags | ||||
| Bus | Nueva Central | Santa Ana Col Del Rio | No tags |
Last refresh of the prices: Today at 9:18 AM CST.
Get from Guadalajara to Santa Ana
The journey takes about 1 day, 45 minutes and with fares starting at just $128, it presents an excellent value for a comfortable ride.
Where are the popular stops in Guadalajara and Santa Ana?
Stops in Guadalajara
- ATerminal de Autobuses de Guadalajara, Carretera Libre a Zapotlanejo y entronque carretera a Tonalá Km. 1.5, 44100 Guadalajara
- B
Estación Juárez Parada de Autobuses
Av. Del Federalismo Nte. 800 (esq. Av. Juárez), 44100 Guadalajara, Jalisco, Mexico - C
Terminal de Autobuses de Tlaquepaque
Anillo Periférico Sur #8010, Col. Santa María Tequepexpan, 45601 Tlaquepaque, Jalisco - D
Guadalajara Airport
- E
Terminal de Autobuses Nuevo Milenio de Zapopan
Carretera A Nogales No. 1110, Casi Esq. Av. Aviación (Col. San Juan de Ocotan), 20230 Zapopan, Jal. - F
Forum de Tlaquepaque - Parada de Autobuses
Blvd. Marcelino García Barragán No. 2077 (Col. Lomas del Paradero), 44840, Guadalajara
Stops in Santa Ana
- A
Parada de Autobuses de Santa Ana
Avenida Aldama # 301 entre Cerna y Guerrero - Colonia Centro, 84600 Santa Ana
Compare bus companies
Since 1994, Tufesa has been offering comfortable, safe, and affordable bus travel in the United States (California, Nevada, Utah, Arizona and Texas) and Mexico (Baja California Sur, Sonora, Sinaloa and Guadalajara). Tufesa buses are equipped with comfortable reclining seats, power outlets, bathrooms, and WiFi (only in Mexico). Tickets are non-refundable, but you can exchange them up to 1 hour before travel time for a small fee. The company accepts e-tickets, so you don't have to worry about printing your boarding pass. With over 5 daily trips, you'll surely find a convenient trip that fits your needs and your schedule.
Frequently asked questions about traveling from Guadalajara, MX to Santa Ana, SON, MX by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Guadalajara to Santa Ana?
The cheapest bus tickets from Guadalajara to Santa Ana start from $128. The average price for this route is around $132. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Guadalajara to Santa Ana?
The average bus trip duration from Guadalajara to Santa Ana is 1d , covering a distance of 834 miles (1345 km). The quickest bus can get you there in 21h 50m and is operated by Tufesa.
Which bus companies service the Guadalajara to Santa Ana route?
Several major train operators operate on this route with 29 trains available per day.
What is the earliest and latest departure time for the bus from Guadalajara to Santa Ana?
The earliest bus departs from Guadalajara to Santa Ana at 12:16am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Guadalajara to Santa Ana?
A bus trip from Guadalajara to Santa Ana generates an estimated 34 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Guadalajara, MX to Santa Ana, SON, MX was searched and found on Jan 26, 2026 with a price of $133To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Guadalajara, MX to Santa Ana, SON, MX, as early as possible.
You can expect to pay from $133 to $157 for a bus ticket from Guadalajara, MX to Santa Ana, SON, MX based on the last 2 days. You can expect to find the cheapest price for the trip at $133 which is on 2026-01-26.
