Bus from Chicago to St. Louis: Tickets & Schedules
Next bus departures
Next departures for Chicago to St. Louis on September 6
Operated by
Vehicle type
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Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
CheapestFastest
Next departures for Chicago to St. Louis on September 7
Operated by
Vehicle type
Departure time
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Trip duration
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Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
CheapestFastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on September 8
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Downtown Greyhound Station
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on September 9
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
CheapestFastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on September 10
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on September 11
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on September 12
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on September 13
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
537-517 W. Jackson Blvd
Gateway Station
No tags
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Last refresh of the prices: Today at 3:55 PM CDT.
Compare 2 ways to go from Chicago to St. Louis
We recommend taking the train
Among the sustainable travel choices, the Train stands out as a good way to reach St. Louis. The journey takes about 5 hours 1 minute and with fares starting at just $30, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Chicago St. Louis recent customer reviews
It was an awful experience never I will book a flixbus. Bus did not come on time it was more than 6 hours late and no one can ready for the replay. Zero services.
1.0 out of 5 stars
Harshil Jagdish U.
Workers at the Greyhound station of Chicago and St. Louis were very helpful. Not the friendliest, but helpful indeed. The bus itself was over 2hrs late with no explanation and we were not told how long of a delay it would be upon initial announcement.
2.0 out of 5 stars
Amber H.
Our bus was supposed to leave Chicago at 1:30 in the morning, we did not leave until 5:30. It was very late and a huge inconvenience. The station was also very dirty, so there was not clean places to sit and wait.
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $182
Users have shared positive experiences with Amtrak, highlighting the smooth and comfortable rides. They appreciated the spacious seating that allowed for relaxation and sleep during their journeys. The cleanliness of the train was noted, along with effective announcements encouraging a respectful environment by keeping noise levels down. Overall, travelers were pleased with their trips compared to past experiences, noting improvements in food quality as well.
Amtrak Chicago St. Louis recent customer reviews
It was wonderful! It has been about 30 years since I have rode Amtrak . very pleased with the ride and I was able to enjoy my visit by not being tired because of having to drive to Chicago.
5.0 out of 5 stars
Tracy A.
My trip experience was very quiet and smooth. I was in comfort and had plenty of space where I could relax and get some sleep. My trip was 4 1/2 hours.
4.0 out of 5 stars
Rosemarie H.
Everything was fine, senior customer assistance, smooth ride,nice seating all good
Frequently asked questions about traveling from Chicago to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to St. Louis?
The cheapest bus tickets from Chicago to St. Louis start from $41. The average price for this route is around $51. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to St. Louis?
The average bus trip duration from Chicago to St. Louis is 8h 10m, covering a distance of 259 miles (417 km). The quickest bus can get you there in 4h 40m and is operated by FlixBus.
Which bus companies service the Chicago to St. Louis route?
What is the earliest and latest departure time for the bus from Chicago to St. Louis?
The earliest bus departs from Chicago to St. Louis at 12:15am. And the latest bus departs at 11:45pm.
What are the CO₂ emissions for the bus trip from Chicago to St. Louis?
A bus trip from Chicago to St. Louis generates an estimated 10.41135 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Chicago to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Burlington Trailways, with an average rating of 4.2 out of 5 stars based on 20 reviews.
Which bus company has the best Wi-Fi from Chicago to St. Louis?
Based on reviews on Busbud, the bus company Burlington Trailways has the best Wi-Fi rating with a score of 5.0.
Which bus company has the most timely service from Chicago to St. Louis?
According to Busbud traveler reviews, the most timely bus company on this route is Burlington Trailways, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from Chicago to St. Louis?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Burlington Trailways, with a cleanliness rating of 5.0 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
09/04
$76
09/05
$63
Today
$81
09/07
$90
09/08
$61
09/09
$42
09/10
$39
09/11
$41
The cheapest trip from Chicago to St. Louis was searched and found on Sep 10, 2026 with a price of $39
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to St. Louis, as early as possible.
You can expect to pay from $39 to $161 for a bus ticket from Chicago to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $39 which is on 2026-09-10.
Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Chicago to St. Louis was searched and found on Sep 10, 2026 with a price of $39
