Next departures for Madrid to Brussels on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Madrid (South)
Midi
Cheapest
Bus
Aeropuerto Madrid - Barajas T4 (E)
Brussels-South (Gare du Midi)
Fastest
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels North Train Station
No tags
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Next departures for Madrid to Brussels on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Estación Sur
Brussels-South (Gare du Midi)
Cheapest
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels South (Gare du Midi)
Fastest
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels North Train Station
No tags
Bus
Madrid (South)
Brussels Airport
No tags
Next departures for Madrid to Brussels on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Estación Sur
Brussels-South (Gare du Midi)
Cheapest
Bus
Aeropuerto Madrid - Barajas T4 (E)
Brussels-South (Gare du Midi)
Fastest
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels North Train Station
No tags
Bus
Madrid (South)
Brussels Airport
No tags
Next departures for Madrid to Brussels on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Madrid (South)
Brussels North Train Station
Cheapest
Bus
Aeropuerto Madrid - Barajas T4 (E)
Brussels-South (Gare du Midi)
Fastest
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels North Train Station
No tags
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Next departures for Madrid to Brussels on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Estación Sur
Brussels-South (Gare du Midi)
Cheapest
Bus
Aeropuerto Madrid - Barajas T4 (E)
Brussels-South (Gare du Midi)
Fastest
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels North Train Station
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels South (Gare du Midi)
No tags
Next departures for Madrid to Brussels on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Estación Sur
Brussels-South (Gare du Midi)
Cheapest
Bus
Aeropuerto Madrid - Barajas T4 (E)
Brussels-South (Gare du Midi)
Fastest
Bus
Estación Sur
Brussels-South (Gare du Midi)
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels North Train Station
No tags
Bus
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Brussels South (Gare du Midi)
No tags
Last refresh of the prices: Yesterday at 7:19 PM CET.
Compare 2 ways to go from Madrid to Brussels
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Brussels. The journey takes about 17 hours 30 minutes and with fares starting at just $73, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11145 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $50
BlaBlaBus Madrid Brussels recent customer reviews
The driver from Madrid was so stressed and rude to passengers. Did not want any one one to ask him anything during the stop or pause
Frequently asked questions about traveling from Madrid to Brussels by bus
What is the travel distance from Madrid to Brussels?
The distance separating Madrid and Brussels is 818 miles (1318 km).
What are the departure and arrival stations when taking the bus from Madrid to Brussels?
The majority of buses traveling from Madrid to Brussels start their journey at Estación Sur and wind up at Brussels South (Gare du Midi). These are the most popular pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Brussels?
Once in Brussels, you can start exploring the city and discover its surroundings. The top sights and things to do are Couleur Café Music Festival, Belgian Beer Weekend in Brussels! The Iris events, Brussels' Christmas market - Winter Wonders and Pride Festival in Brussels.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/20
$142
11/21
$111
Today
$112
11/23
$82
11/24
$65
11/25
$68
11/26
$60
11/27
$63
The cheapest trip from Madrid to Brussels was searched and found on Nov 26, 2025 with a price of $60
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Madrid to Brussels, as early as possible.
You can expect to pay from $60 to $209 for a bus ticket from Madrid to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $60 which is on 2025-11-26.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Madrid to Brussels?
The bus is the cheapest travel choice for this destination
The cheapest trip from Madrid to Brussels was searched and found on Nov 26, 2025 with a price of $60
The bus is the cheapest travel choice for this destination
