Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus Station | Gateway Station | No tags | ||||
| Bus | Bus Station | Gateway Station | No tags | ||||
| Bus | Bus Station | Gateway Station | No tags | ||||
| Bus | Bus Station | Gateway Station | No tags | ||||
FlixBus + Greyhound | Bus | Bus Station | Gateway Station | No tags |
Get from Myrtle Beach to St. Louis
The journey takes about 20 hours 15 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.
Where are the popular stops in Myrtle Beach and St. Louis?
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Myrtle Beach to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Myrtle Beach to St. Louis?
The cheapest bus tickets from Myrtle Beach to St. Louis start from $124. The average price for this route is around $138. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Myrtle Beach to St. Louis?
The average bus trip duration from Myrtle Beach to St. Louis is 20h 15m, covering a distance of 716 miles (1154 km). The quickest bus can get you there in 1d 3h and is operated by Greyhound.
Which bus companies service the Myrtle Beach to St. Louis route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Myrtle Beach to St. Louis?
The earliest bus departs from Myrtle Beach to St. Louis at 1:55pm. And the latest bus departs at 1:55pm.
What are the CO₂ emissions for the bus trip from Myrtle Beach to St. Louis?
A bus trip from Myrtle Beach to St. Louis generates an estimated 29 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Myrtle Beach to St. Louis was searched and found on Jan 12, 2026 with a price of $132To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Myrtle Beach to St. Louis, as early as possible.
You can expect to pay from $132 to $132 for a bus ticket from Myrtle Beach to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $132 which is on 2026-01-12.
Top traveled bus routes
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Popular bus departures from Myrtle Beach
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