Bus Roanoke to Knoxville: Trip Overview
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Roanoke to Knoxville Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Roanoke to Knoxville.
We make it our job to connect you with the most dependable bus companies that cover bus service from Roanoke to Knoxville.
From cheap bus tickets to more luxurious buses traveling from Roanoke to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Roanoke and Knoxville?
Frequently asked questions for your trip Roanoke - Knoxville
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Knoxville was searched and found on May 14, 2025 with a price of $36To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Knoxville, as early as possible.
You can expect to pay from $36 to $41 for a bus ticket from Roanoke to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at $36 which is on 2025-05-14.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Roanoke to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Roanoke to Knoxville.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Roanoke to Knoxville that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Roanoke to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Top traveled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
People from around the world trust Busbud
Popular Buses Connecting Roanoke
Buses Leaving from Roanoke
- Bus from Roanoke to Denton
- Bus Roanoke - Blacksburg
- Roanoke - Lynchburg
- Bus from Roanoke to Dallas
- Bus Roanoke - Charlotte
- Roanoke - Kansas City
- Bus from Roanoke to New York
- Bus Roanoke - Richmond
- Roanoke - Washington
- Bus from Roanoke to Raleigh
- Bus Roanoke - Norfolk
- Roanoke - Baltimore
- Bus from Roanoke to Atlanta
- Bus Roanoke - Charlottesville
Buses Going to Roanoke
- Bus from Richmond to Roanoke
- Bus Burlington - Roanoke
- Blacksburg - Roanoke
- Bus from Virginia Beach to Roanoke
- Bus Baltimore - Roanoke
- Harrisburg - Roanoke
- Bus from Charlotte to Roanoke
- Bus New York - Roanoke
- Washington - Roanoke
- Bus from Charlottesville to Roanoke
- Bus Norfolk - Roanoke
- Staunton - Roanoke
- Bus from Atlanta to Roanoke
- Bus Lynchburg - Roanoke
Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Lexington
- Bus from Knoxville to Orlando
- Bus Knoxville - Chicago
- Knoxville - New York
- Bus from Knoxville to Nashville
- Bus Knoxville - Atlanta
- Knoxville - Memphis
- Bus from Knoxville to Washington
- Bus Knoxville - Miami
- Knoxville - Jackson
- Bus from Knoxville to Dallas
- Bus Knoxville - Greenville
- Knoxville - Cincinnati
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Richmond - Knoxville
- Bus from Atlanta to Knoxville
- Bus New York - Knoxville
- Greenville - Knoxville
- Bus from Dallas to Knoxville
- Bus Cookeville - Knoxville
- Louisville - Knoxville
- Bus from Lexington to Knoxville
- Bus Washington - Knoxville
- Baltimore - Knoxville