Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Ana | Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali | Cheapest | ||||
 | Bus | Santa Ana Col Del Rio | Tufesa | Fastest | ||||
| Bus | Santa Ana Col Del Rio | Tufesa | No tags | ||||
| Bus | Santa Ana | Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali | No tags | ||||
 | Bus | Santa Ana | Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali | No tags |
Last refresh of the prices: Today at 11:52 AM MST.
Compare 2 ways to go from Santa Ana to Mexicali
Among the sustainable travel choices, the bus stands out as the good way to reach Mexicali. The journey takes about 7 hours 10 minutes and with fares starting at just $47, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$47 - $65 | Average Duration7h 10m | 12kg CO₂e | ||
Carpool | Average Price$28 - $28 | Average Duration7h 30m | 20kg CO₂e |
Where are the popular stops in Santa Ana and Mexicali?
Stops in Santa Ana
- A
Parada de Autobuses de Santa Ana
Avenida Aldama # 301 entre Cerna y Guerrero - Colonia Centro, 84600 Santa Ana
Stops in Mexicali
- A
Terminal de Autobuses de Mexicali
Calzada Independencia No. 1244 (entre Blvd. Anahuac y Lopez Mateos, Col. Centro Civico), 21000 Mexicali - B
Nuevo Mexicali
Blvd. Lázaro Cárdenas 2666 -1 , Fraccionamiento, Col. Nuevo Mexicali - CMéxico 2, Puebla, 21620 Puebla, B.C., Mexico
- D
Apozol Central 27
Apozol Central 27, Zacatecas, Mexicali, B.C., Mexico - E
Bvld Lázaro Cárdenas
Blvrd Lázaro Cárdenas #3295, Mexicali, B.C., Mexico
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Frequently asked questions about traveling from Santa Ana, SON, MX to Mexicali by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Ana to Mexicali?
The cheapest bus tickets from Santa Ana to Mexicali start from $47. The average price for this route is around $55. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Ana to Mexicali?
The average bus trip duration from Santa Ana to Mexicali is 7h 10m, covering a distance of 294 miles (473 km). The quickest bus can get you there in 6h 5m and is operated by Tufesa.
Which bus companies service the Santa Ana to Mexicali route?
Several major bus companies operate on this route with 25 buses available per day, including services from Tufesa, Chihuahuenses, Aguacaliente, Futura, Conexion, Nayar.
What is the earliest and latest departure time for the bus from Santa Ana to Mexicali?
The earliest bus departs from Santa Ana to Mexicali at 12:16am. And the latest bus departs at 11:18pm.
What are the CO₂ emissions for the bus trip from Santa Ana to Mexicali?
A bus trip from Santa Ana to Mexicali generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Santa Ana to Mexicali?
According to Busbud customers, the highest-rated bus company on this route is Tufesa, with an average rating of 3.4 out of 5 stars based on 700 reviews.
Which bus company has the best Wi-Fi from Santa Ana to Mexicali?
Based on reviews on Busbud, the bus company Tufesa has the best Wi-Fi rating with a score of 3.0.
Which bus company has the most timely service from Santa Ana to Mexicali?
According to Busbud traveller reviews, the most timely bus company on this route is Conexion, with a punctuality rating of 3.6 out of 5 stars.
Which bus company has the cleanest buses from Santa Ana to Mexicali?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Tufesa, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, SON, MX to Mexicali was searched and found on Jan 6, 2026 with a price of $54To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, SON, MX to Mexicali, as early as possible.
You can expect to pay from $54 to $65 for a bus ticket from Santa Ana, SON, MX to Mexicali based on the last 2 days. You can expect to find the cheapest price for the trip at $55 which is on 2026-01-07.
Usually Tufesa will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
